ENSMUSG00000041483


Mus musculus

Features
Gene ID: ENSMUSG00000041483
  
Biological name :Zfp281
  
Synonyms : Q99LI5 / Zfp281 / zinc finger protein 281
  
Possible biological names infered from orthology : Q9Y2X9 / ZNF281
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 136624901
Gene end: 136630053
  
Corresponding Affymetrix probe sets: 10350331 (MoGene1.0st)   1426377_at (Mouse Genome 430 2.0 Array)   1452045_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039003
Ensembl peptide - ENSMUSP00000107677
NCBI entrez gene - 226442     See in Manteia.
MGI - MGI:3029290
RefSeq - NM_001160251
RefSeq - NM_177643
RefSeq Peptide - NP_001153723
RefSeq Peptide - NP_808311
swissprot - Q99LI5
Ensembl - ENSMUSG00000041483
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znf281aENSDARG00000000567Danio rerio
 znf281bENSDARG00000035910Danio rerio
 ZNF281ENSGALG00000017376Gallus gallus
 Q9Y2X9ENSG00000162702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61624 / Zfp148 / zinc finger protein 148 / Q9UQR1* / ZNF148*ENSMUSG0000002281127
Q6NZQ6 / Zfp740 / zinc finger protein 740 / Q8NDX6* / ZNF740*ENSMUSG000000468979
Q8JZL0 / Zfp467 / zinc finger protein 467 / Q7Z7K2* / ZNF467*ENSMUSG000000685518


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048863 stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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