ENSMUSG00000022868


Mus musculus

Features
Gene ID: ENSMUSG00000022868
  
Biological name :Ahsg
  
Synonyms : Ahsg / Alpha-2-HS-glycoprotein / P29699
  
Possible biological names infered from orthology : P02765
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 22892042
Gene end: 22899438
  
Corresponding Affymetrix probe sets: 10434689 (MoGene1.0st)   1455093_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023583
NCBI entrez gene - 11625     See in Manteia.
MGI - MGI:107189
RefSeq - NM_013465
RefSeq - NM_001276450
RefSeq Peptide - NP_001263379
RefSeq Peptide - NP_038493
swissprot - P29699
swissprot - Q3UEK9
Ensembl - ENSMUSG00000022868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahsg2ENSDARG00000069293Danio rerio
 AHSGENSGALG00000008601Gallus gallus
 AHSGENSG00000145192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fetub / Q9QXC1 / Fetuin-B / Q9UGM5*ENSMUSG0000002287124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR001363  Proteinase inhibitor I25C, fetuin, conserved site
 IPR025760  Fetuin-A-type cystatin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IDA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030502 negative regulation of bone mineralization IDA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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