ENSMUSG00000022885


Mus musculus

Features
Gene ID: ENSMUSG00000022885
  
Biological name :St6gal1
  
Synonyms : Beta-galactoside alpha-2,6-sialyltransferase 1 / Q64685 / St6gal1
  
Possible biological names infered from orthology : P15907 / ST6 beta-galactoside alpha-2,6-sialyltransferase 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 23224740
Gene end: 23360350
  
Corresponding Affymetrix probe sets: 10434758 (MoGene1.0st)   1420927_at (Mouse Genome 430 2.0 Array)   1420928_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023601
Ensembl peptide - ENSMUSP00000110992
Ensembl peptide - ENSMUSP00000121865
Ensembl peptide - ENSMUSP00000136206
NCBI entrez gene - 20440     See in Manteia.
MGI - MGI:108470
RefSeq - XM_011245848
RefSeq - NM_001252505
RefSeq - NM_001252506
RefSeq - NM_145933
RefSeq - XM_006521873
RefSeq - XM_006521874
RefSeq - XM_006521875
RefSeq - XM_006521876
RefSeq Peptide - NP_001239434
RefSeq Peptide - NP_001239435
RefSeq Peptide - NP_666045
swissprot - D3Z1Z5
swissprot - Q64685
Ensembl - ENSMUSG00000022885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st6gal1ENSDARG00000044514Danio rerio
 ST6GAL1ENSGALG00000005550Gallus gallus
 P15907ENSG00000073849Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q76K27 / St6gal2 / Mus musculus beta galactoside alpha 2,6 sialyltransferase 2 (St6gal2), transcript variant 1, mRNA. / Q96JF0* / ST6 beta-galactoside alpha-2,6-sialyltransferase 2*ENSMUSG0000002417239
St6galnac5 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 / Q9BVH7* / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5*ENSMUSG0000003903714
St6galnac4 / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 / Q9H4F1*ENSMUSG0000007944214
Q9JM95 / St6galnac6 / Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 / AL157935.2*ENSMUSG0000002681113
Q9WUV2 / St6galnac3 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 / Q8NDV1* / ST6 N-acetylgalactosaminide alpha-2,6-sialylt...ENSMUSG0000005254413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006054 N-acetylneuraminate metabolic process ISO
 biological_processGO:0006486 protein glycosylation IMP
 biological_processGO:0009311 oligosaccharide metabolic process IBA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine ISO
 biological_processGO:0097503 sialylation ISO
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity ISO
 molecular_functionGO:0008373 sialyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism
N-Glycan antennae elongation
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: ApcMin/Apc+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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