ENSMUSG00000023010


Mus musculus

Features
Gene ID: ENSMUSG00000023010
  
Biological name :Tmbim6
  
Synonyms : Q9D2C7 / Tmbim6 / transmembrane BAX inhibitor motif containing 6
  
Possible biological names infered from orthology : P55061
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 99392882
Gene end: 99410049
  
Corresponding Affymetrix probe sets: 10426751 (MoGene1.0st)   1451586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125437
Ensembl peptide - ENSMUSP00000155747
Ensembl peptide - ENSMUSP00000155580
Ensembl peptide - ENSMUSP00000125563
Ensembl peptide - ENSMUSP00000023749
Ensembl peptide - ENSMUSP00000124651
Ensembl peptide - ENSMUSP00000124805
Ensembl peptide - ENSMUSP00000125091
Ensembl peptide - ENSMUSP00000125117
Ensembl peptide - ENSMUSP00000125318
NCBI entrez gene - 110213     See in Manteia.
MGI - MGI:99682
RefSeq - NM_001171035
RefSeq - NM_001171036
RefSeq - NM_026669
RefSeq - NM_001171034
RefSeq Peptide - NP_001164505
RefSeq Peptide - NP_001164507
RefSeq Peptide - NP_080945
RefSeq Peptide - NP_001164506
swissprot - Q9D2C7
swissprot - E0CXR0
swissprot - E0CX98
swissprot - E0CZE8
Ensembl - ENSMUSG00000023010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tegtENSDARG00000077934Danio rerio
 P55061ENSG00000139644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006213  Bax inhibitor 1, conserved site
 IPR006214  Bax inhibitor 1-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol ISO
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0051025 negative regulation of immunoglobulin secretion IMP
 biological_processGO:0060702 negative regulation of endoribonuclease activity IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:1902065 response to L-glutamate ISO
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1904721 obsolete negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response IMP
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane ISO
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0060698 endoribonuclease inhibitor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf4tm1Bas/Fgf4tm1Bas
Genetic Background: involves: 129S6/SvEvTac

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf4tm1Bas/Fgf4tm1Bas
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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