ENSMUSG00000023073


Mus musculus

Features
Gene ID: ENSMUSG00000023073
  
Biological name :Slc10a2
  
Synonyms : P70172 / Slc10a2 / solute carrier family 10, member 2
  
Possible biological names infered from orthology : Q12908
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 5083219
Gene end: 5105351
  
Corresponding Affymetrix probe sets: 10576901 (MoGene1.0st)   1446368_at (Mouse Genome 430 2.0 Array)   1450245_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023835
NCBI entrez gene - 20494     See in Manteia.
MGI - MGI:1201406
RefSeq - NM_011388
RefSeq Peptide - NP_035518
swissprot - P70172
swissprot - Q0VBB8
Ensembl - ENSMUSG00000023073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc10a2ENSDARG00000014916Danio rerio
 SLC10A2ENSGALG00000016858Gallus gallus
 Q12908ENSG00000125255Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CXB2 / Slc10a6 / Solute carrier family 10 member 6 / Q3KNW5*ENSMUSG0000002932144
Q3UEZ8 / Slc10a4 / solute carrier family 10 (sodium/bile acid cotransporter family), member 4 / Q96EP9* / solute carrier family 10 member 4*ENSMUSG0000002921934
O08705 / Slc10a1 / solute carrier family 10 (sodium/bile acid cotransporter family), member 1 / Q14973* / solute carrier family 10 member 1*ENSMUSG0000002113532
Q5PT54 / Slc10a5 / solute carrier family 10 (sodium/bile acid cotransporter family), member 5 / Q5PT55* / solute carrier family 10 member 5*ENSMUSG0000005892124
P21129 / Slc10a3 / solute carrier family 10 (sodium/bile acid cotransporter family), member 3 / P09131* / solute carrier family 10 member 3*ENSMUSG0000003280621
Gm5868 / Q96EP9* / SLC10A4* / solute carrier family 10 member 4*ENSMUSG0000006020412


Protein motifs (from Interpro)
Interpro ID Name
 IPR002657  Bile acid:sodium symporter/arsenical resistance protein Acr3
 IPR004710  Bile acid:sodium symporter
 IPR030207  Solute carrier family 10 member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0015721 bile acid and bile salt transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0008508 bile acid:sodium symporter activity IBA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Slc10a2tm1Pda/Slc10a2tm1Pda
Genetic Background: either: B6.129P2-Slc10a2tm1Pda or (involves: 129P2/OlaHsd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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