ENSMUSG00000023106


Mus musculus

Features
Gene ID: ENSMUSG00000023106
  
Biological name :Denr
  
Synonyms : Denr / Density-regulated protein / Q9CQJ6
  
Possible biological names infered from orthology : density regulated re-initiation and release factor / O43583
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 123907175
Gene end: 123928835
  
Corresponding Affymetrix probe sets: 10525657 (MoGene1.0st)   1420367_at (Mouse Genome 430 2.0 Array)   1420368_at (Mouse Genome 430 2.0 Array)   1446948_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023869
Ensembl peptide - ENSMUSP00000126174
NCBI entrez gene - 68184     See in Manteia.
MGI - MGI:1915434
RefSeq - XM_011248238
RefSeq - NM_026603
RefSeq - XM_006530452
RefSeq Peptide - NP_080879
swissprot - Q9CQJ6
swissprot - E9Q0G1
Ensembl - ENSMUSG00000023106
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 denrENSDARG00000037229Danio rerio
 DENRENSGALG00000003795Gallus gallus
 DENRENSG00000139726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001950  SUI1 domain
 IPR005872  Archaeal/bacterial translation initiation factor SUI1
 IPR005873  Density-regulated protein DRP1
 IPR036877  SUI1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001731 formation of translation preinitiation complex IEA
 biological_processGO:0002188 translation reinitiation IBA
 biological_processGO:0002192 IRES-dependent translational initiation of linear mRNA IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0032790 ribosome disassembly IEA
 biological_processGO:0075522 IRES-dependent viral translational initiation IEA
 cellular_componentGO:0005840 ribosome IBA
 cellular_componentGO:0070992 translation initiation complex IBA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0043022 ribosome binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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