ENSMUSG00000023336


Mus musculus

Features
Gene ID: ENSMUSG00000023336
  
Biological name :Wfdc1
  
Synonyms : Q9ESH5 / WAP four-disulfide core domain 1 / Wfdc1
  
Possible biological names infered from orthology : Q9HC57
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 119666365
Gene end: 119688222
  
Corresponding Affymetrix probe sets: 10575917 (MoGene1.0st)   1431335_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024107
Ensembl peptide - ENSMUSP00000148437
NCBI entrez gene - 67866     See in Manteia.
MGI - MGI:1915116
RefSeq - NM_023395
RefSeq Peptide - NP_075884
swissprot - Q3UQ76
swissprot - Q9CQZ8
swissprot - Q9ESH5
Ensembl - ENSMUSG00000023336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wfdc1ENSDARG00000058003Danio rerio
 WFDC1ENSGALG00000005503Gallus gallus
 WFDC1ENSG00000103175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008197  WAP-type "four-disulfide core" domain
 IPR036645  Elafin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0061045 negative regulation of wound healing IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ay/a,Sik2tm1Htake/Sik2+
Genetic Background: C57BL/6-Sik2tm1Htake

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Ay/a,Sik2tm1Htake/Sik2+
Genetic Background: C57BL/6-Sik2tm1Htake

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ay/a,Sik2tm1Htake/Sik2+
Genetic Background: C57BL/6-Sik2tm1Htake

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ay/a,Sik2tm1Htake/Sik2+
Genetic Background: C57BL/6-Sik2tm1Htake

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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