ENSMUSG00000023456


Mus musculus

Features
Gene ID: ENSMUSG00000023456
  
Biological name :Tpi1
  
Synonyms : P17751 / Tpi1 / Triosephosphate isomerase
  
Possible biological names infered from orthology : P60174 / triosephosphate isomerase 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124810586
Gene end: 124814296
  
Corresponding Affymetrix probe sets: 10547830 (MoGene1.0st)   1415918_a_at (Mouse Genome 430 2.0 Array)   1435659_a_at (Mouse Genome 430 2.0 Array)   1452927_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125292
Ensembl peptide - ENSMUSP00000130858
NCBI entrez gene - 21991     See in Manteia.
MGI - MGI:98797
RefSeq - NM_009415
RefSeq Peptide - NP_033441
swissprot - H7BXC3
swissprot - P17751
Ensembl - ENSMUSG00000023456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpi1aENSDARG00000025012Danio rerio
 tpi1bENSDARG00000040988Danio rerio
 TPI1ENSGALG00000014526Gallus gallus
 TPI1ENSG00000111669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000652  Triosephosphate isomerase
 IPR013785  Aldolase-type TIM barrel
 IPR020861  Triosephosphate isomerase, active site
 IPR022896  Triosephosphate isomerase, bacterial/eukaryotic
 IPR035990  Triosephosphate isomerase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IDA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006098 pentose-phosphate shunt IEA
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019563 glycerol catabolic process IBA
 biological_processGO:0019682 glyceraldehyde-3-phosphate metabolic process IDA
 biological_processGO:0046166 glyceraldehyde-3-phosphate biosynthetic process IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004807 triose-phosphate isomerase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Glycolysis
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tpi1a-M1Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Tpi1a-M2Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Tpi1a-M3Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Tpi1a-M4Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Gjb1tm1Kwi/Gjb1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ppargtm1Tka/Pparg+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tpi1a-M2Neu/Tpi1a-M2Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Tpi1a-M3Neu/Tpi1a-M3Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Tpi1a-M4Neu/Tpi1a-M4Neu
Genetic Background: involves: 101/El * C3H/El

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023456 Tpi1 / P17751 / Triosephosphate isomerase / P60174* / triosephosphate isomerase 1*  / complex






 

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