ENSMUSG00000023781


Mus musculus

Features
Gene ID: ENSMUSG00000023781
  
Biological name :Hes7
  
Synonyms : Hes7 / Q8BKT2 / Transcription factor HES-7
  
Possible biological names infered from orthology : hes family bHLH transcription factor 7 / Q9BYE0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69120404
Gene end: 69124055
  
Corresponding Affymetrix probe sets: 10377467 (MoGene1.0st)   1422950_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024543
NCBI entrez gene - 84653     See in Manteia.
MGI - MGI:2135679
RefSeq - XM_017314859
RefSeq - NM_033041
RefSeq - XM_006534556
RefSeq Peptide - NP_149030
swissprot - Q8BKT2
Ensembl - ENSMUSG00000023781
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 her1ENSDARG00000014722Danio rerio
 her11ENSDARG00000002707Danio rerio
 HES7ENSG00000179111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032644  Transcription factor HES-7
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7+
Genetic Background: Not Specified

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Hes7tm2.1Dihz/Hes7+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm2.1Dihz/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hes7tm2Kag/Hes7+
Genetic Background: involves: ICR

Allelic Composition: Hes7tm2.1Dihz/Hes7+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm1.1Dihz/Hes7tm1.1Dihz
Genetic Background: Not Specified

Allelic Composition: Hes7tm2.1Dihz/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm2Kag/Hes7tm2Kag
Genetic Background: involves: ICR

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
Show

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes7tm2Kag/Hes7+
Genetic Background: involves: ICR

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hes7tm1.1Dihz/Hes7tm1.1Dihz
Genetic Background: Not Specified

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hes7tm1.1Dihz/Hes7tm1.1Dihz
Genetic Background: Not Specified

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0004612 fusion of vertebral bodies "improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004645 decreased vertebrae number "a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hes7tm2.1Dihz/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005224 abnormal left-right axis symmetry of the somites "anomaly in the formation or development of the somites in relation to the left and right sides of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hes7tm1.1Ybes/Hes7tm1.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Hes7tm3.1Ybes/Hes7tm3.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0005227 abnormal vertebral body development "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005229 abnormal intervertebral disk development "anomalous fromation of the cartilagenous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hes7tm2.1Dihz/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm1Kag/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hes7tm1.1Dihz/Hes7tm1.1Dihz
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hes7tm2.1Dihz/Hes7tm2.1Dihz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hes7tm3.1Dihz/Hes7tm3.1Dihz
Genetic Background: involves: 129 * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hes7tm1.1Dihz/Hes7tm1.1Dihz
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
Show

Allelic Composition: Hes7tm2Kag/Hes7+
Genetic Background: involves: ICR

 MP:0012669 abnormal somite segmentation clock "anomaly or loss of the oscillatory mechanism governed by periodic shifts in gene expression and operating in the presomitic mesoderm that drives the regular periodicity with which somites are formed in the course of vertebrate segmentation. The total number of somites formed and the periodicity with which they are produced are species-specific parameters (e.g. humans have 33 somites with a somitogenesis period of approximately 6 hours while mice have 65 somites with a period of approximately 2 hours)" [http://en.wikipedia.org/wiki/Somitogenesis, MGI:anna, PMID:22274695]
Show

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0012728 abnormal somite border morphology "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]
Show

Allelic Composition: Hes7tm2.1Ybes/Hes7tm2.1Ybes
Genetic Background: involves: C57BL/6 * CBA * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr