ENSMUSG00000023940


Mus musculus

Features
Gene ID: ENSMUSG00000023940
  
Biological name :Sgo1
  
Synonyms : Q9CXH7 / Sgo1 / Shugoshin 1
  
Possible biological names infered from orthology : Q5FBB7
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 53674786
Gene end: 53689333
  
Corresponding Affymetrix probe sets: 10451805 (MoGene1.0st)   1418919_at (Mouse Genome 430 2.0 Array)   1439510_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024736
NCBI entrez gene - 72415     See in Manteia.
MGI - MGI:1919665
RefSeq - XM_017317658
RefSeq - NM_028232
RefSeq - XM_011246642
RefSeq Peptide - NP_082508
swissprot - Q9CXH7
Ensembl - ENSMUSG00000023940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgo1ENSDARG00000103907Danio rerio
 SGO1ENSGALG00000011281Gallus gallus
 SGO1ENSG00000129810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011515  Shugoshin, C-terminal
 IPR011516  Shugoshin, N-terminal coiled-coil domain
 IPR028321  Shugoshin 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore ISS
 biological_processGO:0010457 centriole-centriole cohesion ISS
 biological_processGO:0045132 meiotic chromosome segregation ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071962 mitotic sister chromatid cohesion, centromeric ISO
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000779 condensed chromosome, centromeric region ISO
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0019900 kinase binding ISO


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0012436 increased colon tumor incidence "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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