ENSMUSG00000023952


Mus musculus

Features
Gene ID: ENSMUSG00000023952
  
Biological name :Gtpbp2
  
Synonyms : GTP-binding protein 2 / Gtpbp2 / Q3UJK4
  
Possible biological names infered from orthology : Q9BX10
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 46161032
Gene end: 46169370
  
Corresponding Affymetrix probe sets: 10445442 (MoGene1.0st)   1416690_at (Mouse Genome 430 2.0 Array)   1416691_at (Mouse Genome 430 2.0 Array)   1442305_at (Mouse Genome 430 2.0 Array)   1448437_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128517
Ensembl peptide - ENSMUSP00000128049
Ensembl peptide - ENSMUSP00000131772
Ensembl peptide - ENSMUSP00000133050
Ensembl peptide - ENSMUSP00000024748
Ensembl peptide - ENSMUSP00000127896
NCBI entrez gene - 56055     See in Manteia.
MGI - MGI:1860138
RefSeq - XM_017317583
RefSeq - NM_001145979
RefSeq - NM_019581
RefSeq - XM_006524651
RefSeq - XM_006524652
RefSeq - XM_017317582
RefSeq Peptide - NP_062527
RefSeq Peptide - NP_001139451
swissprot - F6RLV6
swissprot - F7A4M1
swissprot - E9Q004
swissprot - E9PVQ4
swissprot - Q3UJK4
swissprot - E9QA45
Ensembl - ENSMUSG00000023952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtpbp2bENSDARG00000071059Danio rerio
 ENSGALG00000010315Gallus gallus
 GTPBP2ENSG00000172432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gtpbp1 / O08582 / GTP-binding protein 1 / O00178*ENSMUSG0000004253544


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035531  GTP binding protein 1-like, GTP-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,Tg(n-TRtct5)609Slac/0
Genetic Background: C57BL/6J-Gtpbp2nmf205 Tg(n-TRtct5)609Slac

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,Tg(n-TRtct5)574Slac/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Gtpbp2nmf205/Gtpbp2tm1Ynim,n-TRtct5m1J/n-TRtct5m1J
Genetic Background: (C57BL/6J-Gtpbp2nmf205/J x B6.Cg-Gtpbp2tm1Ynim)F1

Allelic Composition: Gtpbp2tm1Ynim/Gtpbp2tm1Ynim,n-TRtct5m1J/n-TRtct5m1J
Genetic Background: B6.Cg-Gtpbp2tm1Ynim

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: A/J * C57BL/6J

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: AKR/J * C57BL/6J

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * C57BL/6NJ

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * MA/MyJ

Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * NOD/ShiLtJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhm1H/Crh+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Gtpbp2tm1Ynim/Gtpbp2tm1Ynim,n-TRtct5m1J/n-TRtct5m1J
Genetic Background: B6.Cg-Gtpbp2tm1Ynim

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gtpbp2tm1Ynim/Gtpbp2tm1Ynim,n-TRtct5m1J/n-TRtct5m1J
Genetic Background: B6.Cg-Gtpbp2tm1Ynim

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008103 amacrine cell degeneration "a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008265 abnormal hippocampus CA2 region morphology 
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gtpbp2tm1Ynim/Gtpbp2tm1Ynim,n-TRtct5m1J/n-TRtct5m1J
Genetic Background: B6.Cg-Gtpbp2tm1Ynim

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0013273 abnormal translational elongation "any anomaly in the process of successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis" [GO:0006414]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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