ENSMUSG00000024032


Mus musculus

Features
Gene ID: ENSMUSG00000024032
  
Biological name :Tff1
  
Synonyms : Q08423 / Tff1 / trefoil factor 1
  
Possible biological names infered from orthology : P04155
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 31161396
Gene end: 31165053
  
Corresponding Affymetrix probe sets: 10449666 (MoGene1.0st)   1448156_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024831
NCBI entrez gene - 21784     See in Manteia.
MGI - MGI:88135
RefSeq - XM_006524030
RefSeq - NM_009362
RefSeq Peptide - NP_033388
swissprot - Q08423
swissprot - Q149Y8
Ensembl - ENSMUSG00000024032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFF1ENSG00000160182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tff2 / trefoil factor 2 (spasmolytic protein 1) / Q03403* / trefoil factor 2*ENSMUSG0000002402844
Tff3 / Q62395 / Trefoil factor 3 ENSMUSG0000002402936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000519  P-type trefoil domain
 IPR017957  P-type trefoil, conserved site
 IPR017994  P-type trefoil, chordata
 IPR028824  Trefoil factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007586 digestion IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030277 maintenance of gastrointestinal epithelium IEA
 biological_processGO:0042060 wound healing IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tff1tm1Mrio/Tff1tm1Mrio
Genetic Background: involves: 129S2/SvPas

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tff1tm1Mrio/Tff1tm1Mrio
Genetic Background: involves: 129S2/SvPas

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tff1tm1Mrio/Tff1tm1Mrio
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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