ENSMUSG00000024045


Mus musculus

Features
Gene ID: ENSMUSG00000024045
  
Biological name :Akap8
  
Synonyms : Akap8 / A-kinase anchor protein 8 / Q9DBR0
  
Possible biological names infered from orthology : A-kinase anchoring protein 8 / O43823
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 32303676
Gene end: 32321153
  
Corresponding Affymetrix probe sets: 10449839 (MoGene1.0st)   1433669_at (Mouse Genome 430 2.0 Array)   1450983_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002699
NCBI entrez gene - 56399     See in Manteia.
MGI - MGI:1928488
RefSeq - XM_006524666
RefSeq - NM_019774
RefSeq - XM_006524663
RefSeq - XM_006524664
RefSeq - XM_006524665
RefSeq Peptide - NP_062748
swissprot - Q059U9
swissprot - Q9DBR0
Ensembl - ENSMUSG00000024045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP8ENSG00000105127Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akap8l / A-kinase anchoring protein 8 like / Q9ULX6*ENSMUSG0000000262530
Zfp326 / zinc finger protein 326 / Q5BKZ1* / ZNF326*ENSMUSG0000002929023


Protein motifs (from Interpro)
Interpro ID Name
 IPR007071  A-kinase anchoring protein 95 (AKAP95)
 IPR026939  At2g23090-like
 IPR034736  Zinc finger C2H2 AKAP95-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007076 mitotic chromosome condensation ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0033127 regulation of histone phosphorylation ISO
 biological_processGO:0044839 cell cycle G2/M phase transition ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0000793 condensed chromosome ISO
 cellular_componentGO:0001939 female pronucleus IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Akap8Gt(XG068)Byg/Akap8+,Fignfi/Fignfi
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

Allelic Composition: Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg,Fignfi/Fign+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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