ENSMUSG00000024127


Mus musculus

Features
Gene ID: ENSMUSG00000024127
  
Biological name :Prepl
  
Synonyms : Prepl / Prolyl endopeptidase-like / Q8C167
  
Possible biological names infered from orthology : Q4J6C6
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 85063477
Gene end: 85090267
  
Corresponding Affymetrix probe sets: 10453373 (MoGene1.0st)   1426345_at (Mouse Genome 430 2.0 Array)   1426346_at (Mouse Genome 430 2.0 Array)   1442060_at (Mouse Genome 430 2.0 Array)   1452034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130967
Ensembl peptide - ENSMUSP00000072239
NCBI entrez gene - 213760     See in Manteia.
MGI - MGI:2441932
RefSeq - NM_145984
RefSeq - XM_006524001
RefSeq - NM_001163622
RefSeq - NM_001163623
RefSeq - NM_001163624
RefSeq Peptide - NP_001157095
RefSeq Peptide - NP_001157096
RefSeq Peptide - NP_666096
RefSeq Peptide - NP_001157094
swissprot - Q8C167
Ensembl - ENSMUSG00000024127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 preplENSDARG00000017853Danio rerio
 PREPLENSGALG00000009981Gallus gallus
 PREPLENSG00000138078Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prep / Q9QUR6 / prolyl endopeptidase / P48147*ENSMUSG0000001984918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002470  Peptidase S9A, prolyl oligopeptidase
 IPR023302  Peptidase S9A, N-terminal domain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070008 serine-type exopeptidase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr