ENSMUSG00000019849


Mus musculus

Features
Gene ID: ENSMUSG00000019849
  
Biological name :Prep
  
Synonyms : Prep / prolyl endopeptidase / Q9QUR6
  
Possible biological names infered from orthology : P48147
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B2
Gene start: 45067203
Gene end: 45167198
  
Corresponding Affymetrix probe sets: 10362941 (MoGene1.0st)   1422796_at (Mouse Genome 430 2.0 Array)   1439942_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097444
NCBI entrez gene - 19072     See in Manteia.
MGI - MGI:1270863
RefSeq - NM_011156
RefSeq Peptide - NP_035286
swissprot - Q543B9
swissprot - Q9QUR6
Ensembl - ENSMUSG00000019849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prepENSDARG00000057151Danio rerio
 PREPENSGALG00000015405Gallus gallus
 PREPENSG00000085377Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prepl / Q8C167 / Prolyl endopeptidase-like / Q4J6C6*ENSMUSG0000002412718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001375  Peptidase S9, prolyl oligopeptidase, catalytic domain
 IPR002470  Peptidase S9A, prolyl oligopeptidase
 IPR002471  Peptidase S9, serine active site
 IPR023302  Peptidase S9A, N-terminal domain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019538 protein metabolic process ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070008 serine-type exopeptidase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: PrepGt(RRM213)Byg/Prep+
Genetic Background: B6.129P2-PrepGt(RRM213)Byg

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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