ENSMUSG00000024137


Mus musculus

Features
Gene ID: ENSMUSG00000024137
  
Biological name :E4f1
  
Synonyms : E4f1 / Mus musculus E4F transcription factor 1 (E4f1), transcript variant 4, mRNA. / Q8CCE9
  
Possible biological names infered from orthology : E4F transcription factor 1 / Q66K89
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24443778
Gene end: 24470313
  
Corresponding Affymetrix probe sets: 10448563 (MoGene1.0st)   1431485_at (Mouse Genome 430 2.0 Array)   1450464_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154556
Ensembl peptide - ENSMUSP00000153746
Ensembl peptide - ENSMUSP00000154438
Ensembl peptide - ENSMUSP00000062344
Ensembl peptide - ENSMUSP00000154444
NCBI entrez gene - 13560     See in Manteia.
MGI - MGI:109530
RefSeq - XM_017317225
RefSeq - NM_001301784
RefSeq - NM_001355708
RefSeq - NM_007893
RefSeq - XM_011246268
RefSeq - XM_011246269
RefSeq - XM_017317223
RefSeq - XM_017317224
RefSeq Peptide - NP_001342637
RefSeq Peptide - NP_031919
RefSeq Peptide - NP_001288713
swissprot - Q8CCE9
Ensembl - ENSMUSG00000024137
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e4f1ENSDARG00000038243Danio rerio
 E4F1ENSGALG00000005900Gallus gallus
 E4F1ENSG00000167967Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009794 regulation of mitotic cell cycle, embryonic IMP
 biological_processGO:0010564 regulation of cell cycle process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
Show

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0001234 absent suprabasal layer "missing suprobasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0009560 absent epidermis stratum granulosum "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: E4f1tm1Pisc/E4f1tm1.1Llca,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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