ENSMUSG00000024212


Mus musculus

Features
Gene ID: ENSMUSG00000024212
  
Biological name :Mllt1
  
Synonyms : Mllt1 / MLLT1, super elongation complex subunit
  
Possible biological names infered from orthology : Q03111
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56892612
Gene end: 56935388
  
Corresponding Affymetrix probe sets: 10452188 (MoGene1.0st)   1421060_at (Mouse Genome 430 2.0 Array)   1434805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025053
NCBI entrez gene - 64144     See in Manteia.
MGI - MGI:1927238
RefSeq - NM_022328
RefSeq - XM_006524778
RefSeq Peptide - NP_071723
swissprot - Q9ERL0
Ensembl - ENSMUSG00000024212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mllt1aENSDARG00000043185Danio rerio
 mllt1bENSDARG00000031709Danio rerio
 MLLT1ENSGALG00000001596Gallus gallus
 MLLT1ENSG00000130382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mllt3 / A2AM29 / myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 / P42568* / MLLT3, super elongation complex subunit*ENSMUSG0000002849652


Protein motifs (from Interpro)
Interpro ID Name
 IPR005033  YEATS


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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