ENSMUSG00000028496


Mus musculus

Features
Gene ID: ENSMUSG00000028496
  
Biological name :Mllt3
  
Synonyms : A2AM29 / Mllt3 / myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
  
Possible biological names infered from orthology : MLLT3, super elongation complex subunit / P42568
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 87769925
Gene end: 88033364
  
Corresponding Affymetrix probe sets: 10514255 (MoGene1.0st)   1429205_at (Mouse Genome 430 2.0 Array)   1431890_a_at (Mouse Genome 430 2.0 Array)   1453622_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131095
Ensembl peptide - ENSMUSP00000127376
Ensembl peptide - ENSMUSP00000128366
Ensembl peptide - ENSMUSP00000129523
Ensembl peptide - ENSMUSP00000077232
NCBI entrez gene - 70122     See in Manteia.
MGI - MGI:1917372
RefSeq - XM_006538253
RefSeq - NM_001286158
RefSeq - NM_027326
RefSeq - NM_029931
RefSeq - XM_006538250
RefSeq Peptide - NP_081602
RefSeq Peptide - NP_084207
RefSeq Peptide - NP_001273087
swissprot - Q3UIA3
swissprot - A2AM29
swissprot - Q9D2P1
swissprot - E9Q3B8
swissprot - E9PXP8
Ensembl - ENSMUSG00000028496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MLLT3ENSGALG00000015078Gallus gallus
 MLLT3ENSG00000171843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mllt1 / MLLT1, super elongation complex subunit / Q03111*ENSMUSG0000002421250


Protein motifs (from Interpro)
Interpro ID Name
 IPR005033  YEATS


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007379 segment specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IEA
 molecular_functionGO:0140030 modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Nyxnob/Y
Genetic Background: involves: BALB/cGr

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008922 abnormal cervical rib "alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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