ENSMUSG00000024254


Mus musculus

Features
Gene ID: ENSMUSG00000024254
  
Biological name :Abcg8
  
Synonyms : Abcg8 / ATP binding cassette subfamily G member 8 / Q9DBM0
  
Possible biological names infered from orthology : Q9H221
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 84676302
Gene end: 84700333
  
Corresponding Affymetrix probe sets: 10447239 (MoGene1.0st)   1420656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035246
Ensembl peptide - ENSMUSP00000126675
Ensembl peptide - ENSMUSP00000127785
NCBI entrez gene - 67470     See in Manteia.
MGI - MGI:1914720
RefSeq - XM_006524826
RefSeq - NM_001286005
RefSeq - NM_001347418
RefSeq - NM_026180
RefSeq Peptide - NP_001272934
RefSeq Peptide - NP_001334347
RefSeq Peptide - NP_080456
swissprot - Q7TSR6
swissprot - Q9DBM0
swissprot - E9Q0P2
Ensembl - ENSMUSG00000024254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg8ENSDARG00000063059Danio rerio
 ABCG8ENSGALG00000009958Gallus gallus
 ABCG8ENSG00000143921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR013525  ABC-2 type transporter
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007588 excretion IMP
 biological_processGO:0010949 negative regulation of intestinal phytosterol absorption ISO
 biological_processGO:0015914 phospholipid transport IMP
 biological_processGO:0015918 sterol transport IMP
 biological_processGO:0030299 intestinal cholesterol absorption IC
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis ISO
 biological_processGO:0045796 negative regulation of intestinal cholesterol absorption ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055092 sterol homeostasis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IMP
 cellular_componentGO:0043190 ATP-binding cassette (ABC) transporter complex ISO
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015248 sterol transporter activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IMP
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Abcg8tm1Elk/Abcg8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002645 abnormal cholesterol absorption "anomalous ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l34J/Myo5ad-l34J
Genetic Background: involves: BALB/cJ * CAST/EiJ

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Abcg8tm1Elk/Abcg8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0010076 abnormal plant sterol concentration "anomaly in the amount per unit of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0010077 increased plant sterol concentration "increased amount per unit of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0010078 increased circulating plant sterol concentration "increase in the amount per unit of phytosterols in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0013437 decreased plant sterol level "decreased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040505 Abcg5 / Q99PE8 / ATP binding cassette subfamily G member 5 / Q9H222*  / complex






 

1 s.

 
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