ENSMUSG00000040505


Mus musculus

Features
Gene ID: ENSMUSG00000040505
  
Biological name :Abcg5
  
Synonyms : Abcg5 / ATP binding cassette subfamily G member 5 / Q99PE8
  
Possible biological names infered from orthology : Q9H222
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 84658234
Gene end: 84683011
  
Corresponding Affymetrix probe sets: 10453318 (MoGene1.0st)   1419393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130783
Ensembl peptide - ENSMUSP00000069495
NCBI entrez gene - 27409     See in Manteia.
MGI - MGI:1351659
RefSeq - NM_031884
RefSeq Peptide - NP_114090
swissprot - E9QA91
swissprot - Q99PE8
Ensembl - ENSMUSG00000040505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg5ENSDARG00000063078Danio rerio
 ABCG5ENSGALG00000009955Gallus gallus
 ABCG5ENSG00000138075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcg2 / ATP binding cassette subfamily G member 2 (Junior blood group) / Q9UNQ0*ENSMUSG0000002980227
Abcg4 / ATP binding cassette subfamily G member 4 / Q9H172*ENSMUSG0000003213124
Abcg3 / Q99P81 / ATP binding cassette subfamily G member 3 / ABCG2* / Q9UNQ0* / ATP binding cassette subfamily G member 2 (Junior blood group)*ENSMUSG0000002929922
Abcg1 / Q64343 / ATP binding cassette subfamily G member 1 / P45844*ENSMUSG0000002403022


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR013525  ABC-2 type transporter
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IBA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007588 excretion IMP
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010949 negative regulation of intestinal phytosterol absorption IEA
 biological_processGO:0030299 intestinal cholesterol absorption IC
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0045796 negative regulation of intestinal cholesterol absorption IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IMP
 cellular_componentGO:0043190 ATP-binding cassette (ABC) transporter complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h3tm1Dgen/Nr1h3tm1Dgen
Genetic Background: Not Specified

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002645 abnormal cholesterol absorption "anomalous ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l34J/Myo5ad-l34J
Genetic Background: involves: BALB/cJ * CAST/EiJ

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0010074 stomatocytosis "deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0010076 abnormal plant sterol concentration "anomaly in the amount per unit of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0010077 increased plant sterol concentration "increased amount per unit of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0010078 increased circulating plant sterol concentration "increase in the amount per unit of phytosterols in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0013437 decreased plant sterol level "decreased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols" [ISBN:0-683-40008-8]
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Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: C57BL/6 * DBA * SJL

Allelic Composition: Abcg5tm1.1Hobb/Abcg5tm1.1Hobb,Abcg8tm1.1Hobb/Abcg8tm1.1Hobb,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0014060 abnormal platelet alpha-granule morphology "any structural anomaly of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0030025 giant platelets "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
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Allelic Composition: Kitltm3.1Pbes/Kitl+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024254 Abcg8 / Q9DBM0 / ATP binding cassette subfamily G member 8 / Q9H221*  / complex






 

1 s.

 
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