ENSMUSG00000024030


Mus musculus

Features
Gene ID: ENSMUSG00000024030
  
Biological name :Abcg1
  
Synonyms : Abcg1 / ATP binding cassette subfamily G member 1 / Q64343
  
Possible biological names infered from orthology : P45844
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 31057698
Gene end: 31115777
  
Corresponding Affymetrix probe sets: 10443730 (MoGene1.0st)   1423570_at (Mouse Genome 430 2.0 Array)   1455221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024829
NCBI entrez gene - 11307     See in Manteia.
MGI - MGI:107704
RefSeq - NM_009593
RefSeq Peptide - NP_033723
swissprot - Q0VDW9
swissprot - Q64343
Ensembl - ENSMUSG00000024030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg1ENSDARG00000063475Danio rerio
 ABCG1ENSGALG00000016164Gallus gallus
 ABCG1ENSG00000160179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcg4 / ATP binding cassette subfamily G member 4 / Q9H172*ENSMUSG0000003213168
Abcg2 / ATP binding cassette subfamily G member 2 (Junior blood group) / Q9UNQ0*ENSMUSG0000002980226
Abcg5 / Q99PE8 / ATP binding cassette subfamily G member 5 / Q9H222*ENSMUSG0000004050522
Abcg3 / Q99P81 / ATP binding cassette subfamily G member 3 / ABCG2* / Q9UNQ0* / ATP binding cassette subfamily G member 2 (Junior blood group)*ENSMUSG0000002929922


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005284  Pigment precursor permease/Protein ATP-binding cassette sub-family G
 IPR013525  ABC-2 type transporter
 IPR017871  ABC transporter, conserved site
 IPR020064  ABC transporter, G1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010872 regulation of cholesterol esterification IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux IDA
 biological_processGO:0010888 negative regulation of lipid storage IMP
 biological_processGO:0030301 cholesterol transport IDA
 biological_processGO:0032367 intracellular cholesterol transport ISO
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling IMP
 biological_processGO:0034436 glycoprotein transport IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042987 amyloid precursor protein catabolic process IEA
 biological_processGO:0043691 reverse cholesterol transport IMP
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0071403 cellular response to high density lipoprotein particle stimulus IDA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0055037 recycling endosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005548 phospholipid transporter activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA
 molecular_functionGO:0034041 sterol-transporting ATPase activity ISO
 molecular_functionGO:0034437 glycoprotein transporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis
HDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen,Tg(APOA1)1Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dag1tm4.1Kcam/Dag1tm4.1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dag1tm4.1Kcam/Dag1tm4.1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: B6.129S4-Ndufs4tm1.1Rpa

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

Allelic Composition: Abcg1tm1Dgen/Abcg1+,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0008690 increased interleukin-23 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024030 Abcg1 / Q64343 / ATP binding cassette subfamily G member 1 / P45844*  / complex






 

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