ENSG00000160179


Homo sapiens

Features
Gene ID: ENSG00000160179
  
Biological name :ABCG1
  
Synonyms : ABCG1 / ATP binding cassette subfamily G member 1 / P45844
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 42199689
Gene end: 42297244
  
Corresponding Affymetrix probe sets: 204567_s_at (Human Genome U133 Plus 2.0 Array)   211113_s_at (Human Genome U133 Plus 2.0 Array)   232081_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381467
Ensembl peptide - ENSP00000381464
Ensembl peptide - ENSP00000381475
Ensembl peptide - ENSP00000414541
Ensembl peptide - ENSP00000291524
Ensembl peptide - ENSP00000339744
Ensembl peptide - ENSP00000354995
NCBI entrez gene - 9619     See in Manteia.
OMIM - 603076
RefSeq - XM_011529807
RefSeq - NM_004915
RefSeq - NM_016818
RefSeq - NM_207174
RefSeq - NM_207627
RefSeq - NM_207628
RefSeq - NM_207629
RefSeq - XM_011529806
RefSeq Peptide - NP_004906
RefSeq Peptide - NP_058198
RefSeq Peptide - NP_997510
RefSeq Peptide - NP_997511
RefSeq Peptide - NP_997512
RefSeq Peptide - NP_997057
swissprot - E9PGV9
swissprot - P45844
swissprot - C9JKD9
Ensembl - ENSG00000160179
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg1ENSDARG00000063475Danio rerio
 ABCG1ENSGALG00000016164Gallus gallus
 Abcg1ENSMUSG00000024030Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCG4 / Q9H172 / ATP binding cassette subfamily G member 4ENSG0000017235068
ABCG2 / Q9UNQ0 / ATP binding cassette subfamily G member 2 (Junior blood group)ENSG0000011877726
ABCG5 / Q9H222 / ATP binding cassette subfamily G member 5ENSG0000013807522


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005284  Pigment precursor permease/Protein ATP-binding cassette sub-family G
 IPR013525  ABC-2 type transporter
 IPR017871  ABC transporter, conserved site
 IPR020064  ABC transporter, G1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process IDA
 biological_processGO:0009720 detection of hormone stimulus NAS
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation TAS
 biological_processGO:0010872 regulation of cholesterol esterification ISS
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010887 negative regulation of cholesterol storage TAS
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0032367 intracellular cholesterol transport IEA
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IMP
 biological_processGO:0033993 response to lipid IDA
 biological_processGO:0034374 low-density lipoprotein particle remodeling ISS
 biological_processGO:0034375 high-density lipoprotein particle remodeling TAS
 biological_processGO:0034436 glycoprotein transport IDA
 biological_processGO:0042632 cholesterol homeostasis IDA
 biological_processGO:0042987 amyloid precursor protein catabolic process IDA
 biological_processGO:0043691 reverse cholesterol transport ISS
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055091 phospholipid homeostasis IMP
 biological_processGO:0071403 cellular response to high density lipoprotein particle stimulus IEA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding IC
 molecular_functionGO:0005548 phospholipid transporter activity IDA
 molecular_functionGO:0015485 cholesterol binding IC
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IDA
 molecular_functionGO:0034041 sterol-transporting ATPase activity IDA
 molecular_functionGO:0034437 glycoprotein transporter activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity NAS


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis
HDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160179 ABCG1 / P45844 / ATP binding cassette subfamily G member 1  / complex






 

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