ENSG00000118777


Homo sapiens

Features
Gene ID: ENSG00000118777
  
Biological name :ABCG2
  
Synonyms : ABCG2 / ATP binding cassette subfamily G member 2 (Junior blood group) / Q9UNQ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q22.1
Gene start: 88090264
Gene end: 88231322
  
Corresponding Affymetrix probe sets: 209735_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426934
Ensembl peptide - ENSP00000237612
Ensembl peptide - ENSP00000426916
Ensembl peptide - ENSP00000426917
NCBI entrez gene - 9429     See in Manteia.
OMIM - 603756
RefSeq - XM_017008853
RefSeq - NM_001257386
RefSeq - NM_001348987
RefSeq - NM_004827
RefSeq - XM_005263354
RefSeq - XM_005263355
RefSeq - XM_005263356
RefSeq - XM_011532420
RefSeq - XM_017008852
RefSeq Peptide - NP_001335915
RefSeq Peptide - NP_001335916
RefSeq Peptide - NP_001335917
RefSeq Peptide - NP_001335918
RefSeq Peptide - NP_004818
RefSeq Peptide - NP_001244315
RefSeq Peptide - NP_001335914
swissprot - A0A024RDD4
swissprot - Q9UNQ0
swissprot - F8S0F2
swissprot - H0YAF1
swissprot - H0YAF3
Ensembl - ENSG00000118777
  
Related genetic diseases (OMIM): 138900 - [Uric acid concentration, serum, QTL1], 138900
  614490 - [Junior blood group system], 614490
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg2aENSDARG00000100075Danio rerio
 abcg2dENSDARG00000016818Danio rerio
 ABCG2ENSGALG00000030677Gallus gallus
 Abcg2ENSMUSG00000029802Mus musculus
 Abcg3ENSMUSG00000029299Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCG4 / Q9H172 / ATP binding cassette subfamily G member 4ENSG0000017235026
ABCG1 / P45844 / ATP binding cassette subfamily G member 1ENSG0000016017926
ABCG5 / Q9H222 / ATP binding cassette subfamily G member 5ENSG0000013807525


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR013525  ABC-2 type transporter
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030256  ATP-binding cassette subfamily G member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0015886 heme transport IEA
 biological_processGO:0033344 cholesterol efflux IBA
 biological_processGO:0042493 response to drug TAS
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0046415 urate metabolic process IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0043235 receptor complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity TAS
 molecular_functionGO:0015232 heme transporter activity TAS
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Abacavir transmembrane transport
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118777 ABCG2 / Q9UNQ0 / ATP binding cassette subfamily G member 2 (Junior blood group)  / complex






 

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