ENSMUSG00000029802


Mus musculus

Features
Gene ID: ENSMUSG00000029802
  
Biological name :Abcg2
  
Synonyms : Abcg2 / ATP binding cassette subfamily G member 2 (Junior blood group)
  
Possible biological names infered from orthology : Q9UNQ0
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 58584523
Gene end: 58695676
  
Corresponding Affymetrix probe sets: 10538640 (MoGene1.0st)   1422906_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120940
Ensembl peptide - ENSMUSP00000145435
Ensembl peptide - ENSMUSP00000144876
Ensembl peptide - ENSMUSP00000138703
Ensembl peptide - ENSMUSP00000138608
Ensembl peptide - ENSMUSP00000122924
Ensembl peptide - ENSMUSP00000031822
Ensembl peptide - ENSMUSP00000109933
Ensembl peptide - ENSMUSP00000114454
NCBI entrez gene - 26357     See in Manteia.
MGI - MGI:1347061
RefSeq - XM_011241362
RefSeq - XM_006506151
RefSeq - XM_006506150
RefSeq - XM_006506149
RefSeq - NM_001355477
RefSeq - XM_006506148
RefSeq - NM_011920
RefSeq Peptide - NP_001342406
RefSeq Peptide - NP_036050
swissprot - S4R2E1
swissprot - S4R2M4
swissprot - D3Z150
swissprot - A0A0N4SWA2
swissprot - A0A0R4J0B6
swissprot - D3YVG8
swissprot - D3YZX5
Ensembl - ENSMUSG00000029802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg2aENSDARG00000100075Danio rerio
 abcg2dENSDARG00000016818Danio rerio
 ABCG2ENSGALG00000030677Gallus gallus
 ABCG2ENSG00000118777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcg3 / Q99P81 / ATP binding cassette subfamily G member 3 / ABCG2* / Q9UNQ0* / ATP binding cassette subfamily G member 2 (Junior blood group)*ENSMUSG0000002929955
Abcg5 / Q99PE8 / ATP binding cassette subfamily G member 5 / Q9H222*ENSMUSG0000004050526
Abcg1 / Q64343 / ATP binding cassette subfamily G member 1 / P45844*ENSMUSG0000002403026
Abcg4 / ATP binding cassette subfamily G member 4 / Q9H172*ENSMUSG0000003213126


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR013525  ABC-2 type transporter
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030256  ATP-binding cassette subfamily G member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0015747 urate transport IEA
 biological_processGO:0015893 drug transport IEA
 biological_processGO:0019389 glucuronoside metabolic process IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0046618 drug export IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060136 embryonic process involved in female pregnancy IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097744 urate salt excretion IEA
 biological_processGO:1904479 negative regulation of intestinal absorption IEA
 biological_processGO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0015238 drug transmembrane transporter activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000341 abnormal bile color "a change in the color of the bile from the normal yellowish brown or green " [J:80519]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Abcg2tm1Ahs/Abcg2tm1Ahs,Tg(Thy1-AppDutch)#Jckr/0
Genetic Background: FVB.Cg-Abcg2tm1Ahs Tg(Thy1-AppDutch)#Jckr

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004147 increased porphyrin level "elevated concentration of porphyrins or protoporphyrins" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005653 phototoxicity "condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance " [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:80519]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0005654 porphyria "aquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if aquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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