ENSMUSG00000032131


Mus musculus

Features
Gene ID: ENSMUSG00000032131
  
Biological name :Abcg4
  
Synonyms : Abcg4 / ATP binding cassette subfamily G member 4
  
Possible biological names infered from orthology : Q9H172
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44273188
Gene end: 44288615
  
Corresponding Affymetrix probe sets: 10592772 (MoGene1.0st)   1424437_s_at (Mouse Genome 430 2.0 Array)   1427732_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124154
Ensembl peptide - ENSMUSP00000124647
Ensembl peptide - ENSMUSP00000124583
Ensembl peptide - ENSMUSP00000034648
Ensembl peptide - ENSMUSP00000123999
NCBI entrez gene - 192663     See in Manteia.
MGI - MGI:1890594
RefSeq - XM_011242421
RefSeq - NM_138955
RefSeq Peptide - NP_620405
swissprot - E0CY02
swissprot - E0CYI8
swissprot - Q91WA9
swissprot - F6XWY6
Ensembl - ENSMUSG00000032131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcg4aENSDARG00000061047Danio rerio
 abcg4bENSDARG00000078068Danio rerio
 ABCG4ENSGALG00000006795Gallus gallus
 ABCG4ENSG00000172350Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcg1 / Q64343 / ATP binding cassette subfamily G member 1 / P45844*ENSMUSG0000002403070
Abcg2 / ATP binding cassette subfamily G member 2 (Junior blood group) / Q9UNQ0*ENSMUSG0000002980227
Abcg5 / Q99PE8 / ATP binding cassette subfamily G member 5 / Q9H222*ENSMUSG0000004050524
Abcg3 / Q99P81 / ATP binding cassette subfamily G member 3 / ABCG2* / Q9UNQ0* / ATP binding cassette subfamily G member 2 (Junior blood group)*ENSMUSG0000002929922


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR013525  ABC-2 type transporter
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015918 sterol transport IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0034041 sterol-transporting ATPase activity IBA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dag1tm4.1Kcam/Dag1tm4.1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abcg1tm1Dgen/Abcg1+,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dag1tm4.1Kcam/Dag1tm4.1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcg1tm1Dgen/Abcg1+,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen,Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032131 Abcg4 / ATP binding cassette subfamily G member 4 / Q9H172*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr