ENSMUSG00000024357


Mus musculus

Features
Gene ID: ENSMUSG00000024357
  
Biological name :Sil1
  
Synonyms : Nucleotide exchange factor SIL1 / Q9EPK6 / Sil1
  
Possible biological names infered from orthology : Q9H173 / SIL1 nucleotide exchange factor
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 35266400
Gene end: 35498925
  
Corresponding Affymetrix probe sets: 10458251 (MoGene1.0st)   1417354_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025215
NCBI entrez gene - 81500     See in Manteia.
MGI - MGI:1932040
RefSeq - XM_011247043
RefSeq - NM_030749
RefSeq - XM_006526365
RefSeq - XM_006526366
RefSeq Peptide - NP_109674
swissprot - Q9EPK6
Ensembl - ENSMUSG00000024357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sil1ENSDARG00000100564Danio rerio
 SIL1ENSGALG00000002457Gallus gallus
 SIL1ENSG00000120725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Sil1wz/Sil1wz
Genetic Background: CXB5/ByJ-Sil1wz

Allelic Composition: Sil1Gt(RST462)Byg/Sil1wz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ

Allelic Composition: Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: B6.129P2-Sil1Gt(RST462)Byg

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

Allelic Composition: Dnajc3tm8663Wcl/Dnajc3tm8663Wcl,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sil1wz/Sil1wz
Genetic Background: CXB5/ByJ-Sil1wz

Allelic Composition: Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: B6.129P2-Sil1Gt(RST462)Byg

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Sil1wz/Sil1wz
Genetic Background: CXB5/ByJ-Sil1wz

Allelic Composition: Sil1Gt(RST462)Byg/Sil1wz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CXB5/ByJ

Allelic Composition: Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: B6.129P2-Sil1Gt(RST462)Byg

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * DBA/2

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Rdp/Terttm1Rdp,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Trp53tm1Tyj Terttm1Rdp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr