ENSMUSG00000024392


Mus musculus

Features
Gene ID: ENSMUSG00000024392
  
Biological name :Bag6
  
Synonyms : Bag6 / Large proline-rich protein BAG6 / Q9Z1R2
  
Possible biological names infered from orthology : BCL2 associated athanogene 6 / P46379
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35135178
Gene end: 35147322
  
Corresponding Affymetrix probe sets: 10444719 (MoGene1.0st)   1433890_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138467
Ensembl peptide - ENSMUSP00000134717
Ensembl peptide - ENSMUSP00000138117
Ensembl peptide - ENSMUSP00000025250
Ensembl peptide - ENSMUSP00000129324
Ensembl peptide - ENSMUSP00000133822
Ensembl peptide - ENSMUSP00000134175
Ensembl peptide - ENSMUSP00000134279
Ensembl peptide - ENSMUSP00000134425
Ensembl peptide - ENSMUSP00000134628
NCBI entrez gene - 224727     See in Manteia.
MGI - MGI:1919439
RefSeq - XM_017317436
RefSeq - XM_006524112
RefSeq - XM_006524113
RefSeq - XM_006524114
RefSeq - XM_006524115
RefSeq - XM_006524116
RefSeq - XM_006524117
RefSeq - XM_006524118
RefSeq - XM_006524119
RefSeq - XM_017317431
RefSeq - XM_017317432
RefSeq - XM_017317433
RefSeq - XM_017317434
RefSeq - XM_017317435
RefSeq - NM_001252468
RefSeq - NM_001252469
RefSeq - NM_057171
RefSeq - XM_006524109
RefSeq - XM_006524110
RefSeq - XM_006524111
RefSeq Peptide - NP_476512
RefSeq Peptide - NP_001239397
RefSeq Peptide - NP_001239398
swissprot - G3V013
swissprot - G3UXT8
swissprot - S4R183
swissprot - S4R224
swissprot - A0A1B0GX81
swissprot - Q3UF95
swissprot - G3UYQ2
swissprot - Q9Z1R2
swissprot - G3UYZ0
swissprot - G3UZT6
Ensembl - ENSMUSG00000024392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bag6ENSDARG00000075892Danio rerio
 bag6lENSDARG00000077531Danio rerio
 BAG6ENSG00000204463Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019954  Ubiquitin conserved site
 IPR021925  Large proline-rich protein BAG6
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002429 immune response-activating cell surface receptor signaling pathway IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009790 embryo development IMP
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0018393 internal peptidyl-lysine acetylation IEA
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045861 negative regulation of proteolysis IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0061857 endoplasmic reticulum stress-induced pre-emptive quality control IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071712 ER-associated misfolded protein catabolic process IEA
 biological_processGO:0071816 tail-anchored membrane protein insertion into ER membrane IEA
 biological_processGO:1904294 positive regulation of ERAD pathway IEA
 biological_processGO:1904378 maintenance of unfolded protein involved in ERAD pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0071818 BAT3 complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0051787 misfolded protein binding IEA
 molecular_functionGO:0070628 proteasome binding IDA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003604 single kidney 
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010979 small ureteric bud "reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010982 abnormal ureteric bud elongation "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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