ENSMUSG00000024397


Mus musculus

Features
Gene ID: ENSMUSG00000024397
  
Biological name :Aif1
  
Synonyms : Aif1 / Allograft inflammatory factor 1 / O70200
  
Possible biological names infered from orthology : P55008
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35170991
Gene end: 35176068
  
Corresponding Affymetrix probe sets: 10450484 (MoGene1.0st)   1418204_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025257
Ensembl peptide - ENSMUSP00000133709
Ensembl peptide - ENSMUSP00000134107
Ensembl peptide - ENSMUSP00000134214
NCBI entrez gene - 11629     See in Manteia.
MGI - MGI:1343098
RefSeq - XM_006523503
RefSeq - XM_006523504
RefSeq - NM_019467
RefSeq Peptide - NP_062340
swissprot - O70200
swissprot - G3UYJ2
swissprot - Q4FJL9
Ensembl - ENSMUSG00000024397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AIF1ENSG00000204472Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aif1l / Q9EQX4 / Allograft inflammatory factor 1-like / Q9BQI0*ENSMUSG0000000186461


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation NAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014739 positive regulation of muscle hyperplasia IEA
 biological_processGO:0016601 Rac protein signal transduction IMP
 biological_processGO:0030041 actin filament polymerization ISO
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051017 actin filament bundle assembly ISO
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0071315 cellular response to morphine IEA
 biological_processGO:0071346 cellular response to interferon-gamma ISS
 biological_processGO:0071447 cellular response to hydroperoxide IEA
 biological_processGO:0071672 negative regulation of smooth muscle cell chemotaxis ISO
 biological_processGO:0071673 positive regulation of smooth muscle cell chemotaxis ISO
 biological_processGO:0090026 positive regulation of monocyte chemotaxis ISO
 biological_processGO:0097178 ruffle assembly NAS
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle ISS
 biological_processGO:2000406 positive regulation of T cell migration ISS
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Adgrf5tm1Shiro/Adgrf5tm1Shiro
Genetic Background: B6.Cg-Adgrf5tm1Shiro

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Adgrf5tm1Shiro/Adgrf5tm1Shiro
Genetic Background: B6.Cg-Adgrf5tm1Shiro

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrf5tm1Shiro/Adgrf5tm1Shiro
Genetic Background: B6.Cg-Adgrf5tm1Shiro

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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