ENSMUSG00000024526


Mus musculus

Features
Gene ID: ENSMUSG00000024526
  
Biological name :Cidea
  
Synonyms : Cell death activator CIDE-A / Cidea / O70302
  
Possible biological names infered from orthology : cell death-inducing DFFA-like effector a / O60543
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 67343564
Gene end: 67367794
  
Corresponding Affymetrix probe sets: 10456392 (MoGene1.0st)   1417956_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025404
NCBI entrez gene - 12683     See in Manteia.
MGI - MGI:1270845
RefSeq - NM_007702
RefSeq Peptide - NP_031728
swissprot - O70302
Ensembl - ENSMUSG00000024526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cideaENSDARG00000098245Danio rerio
 CIDEAENSGALG00000034500Gallus gallus
 CIDEAENSG00000176194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cidec / P56198 / Cell death activator CIDE-3 / Q96AQ7* / cell death inducing DFFA like effector c*ENSMUSG0000003027842
Cideb / O70303 / Cell death activator CIDE-B / Q9UHD4* / cell death-inducing DFFA-like effector b*ENSMUSG0000002221938


Protein motifs (from Interpro)
Interpro ID Name
 IPR003508  CIDE-N domain
 IPR032936  Cell death activator CIDE-A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008219 cell death IDA
 biological_processGO:0010890 positive regulation of sequestering of triglyceride IDA
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0050710 negative regulation of cytokine secretion IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IMP
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IDA
 biological_processGO:1902510 regulation of apoptotic DNA fragmentation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005740 mitochondrial envelope IDA
 cellular_componentGO:0005811 lipid droplet IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Lipid particle organization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009935 abnormal meibomian gland acinus morphology "anomalies of the sac-like structures comprising the sebaceous glands located at the rim of the eyelids and responsible for producing sebum" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0013116 focal hair loss in head/neck region "focal absence of hair in the head and/or neck region, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body" [MGI:Ahmad_Retha, MGI:csmith]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0013375 abnormal sebocyte morphology "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0014053 dry hair "hair characterized by the lack of natural or normal moisture" [MGI:Anna]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030278 Cidec / P56198 / Cell death activator CIDE-3 / Q96AQ7* / cell death inducing DFFA like effector c*  / complex






 

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