Manteia - Molecule gene

ENSMUSG00000024588

Mus musculus

Features

Gene ID:	ENSMUSG00000024588

Biological name :	Fech

Synonyms :	Fech / Mus musculus ferrochelatase (Fech), transcript variant 2, mRNA.

Possible biological names infered from orthology :	ferrochelatase / P22830

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E1
Gene start:	64456550
Gene end:	64489066

Corresponding Affymetrix probe sets:	10459391 (MoGene1.0st) 1418698_a_at (Mouse Genome 430 2.0 Array) 1418699_s_at (Mouse Genome 430 2.0 Array) 1449181_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025484 NCBI entrez gene - 14151 See in Manteia. MGI - MGI:95513 RefSeq - XM_017317829 RefSeq - NM_001348055 RefSeq - NM_007998 RefSeq Peptide - NP_032024 RefSeq Peptide - NP_001334984 swissprot - Q544X6 Ensembl - ENSMUSG00000024588

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fech	ENSDARG00000003462	Danio rerio
FECH	ENSGALG00000038461	Gallus gallus
FECH	ENSG00000066926	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001015	Ferrochelatase
IPR019772	Ferrochelatase, active site
IPR033644	Ferrochelatase, C-terminal
IPR033659	Ferrochelatase, N-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006779	porphyrin-containing compound biosynthetic process	IEA
biological_process	GO:0006783	heme biosynthetic process	IEA
biological_process	GO:0010038	response to metal ion	IEA
biological_process	GO:0010288	response to lead ion	IEA
biological_process	GO:0017085	response to insecticide	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0046501	protoporphyrinogen IX metabolic process	IEA
biological_process	GO:0046685	response to arsenic-containing substance	IEA
biological_process	GO:0051597	response to methylmercury	IEA
biological_process	GO:0070541	response to platinum ion	IEA
biological_process	GO:0071549	cellular response to dexamethasone stimulus	IEA
cellular_component	GO:0005739	mitochondrion	IEA
molecular_function	GO:0004325	ferrochelatase activity	IEA
molecular_function	GO:0016829	lyase activity	IEA

Pathways (from Reactome)

Pathway description

Heme biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0000611	jaundice	"clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0001202	skin photosensitivity	"abnormally heightened reactivity of the skin to sunlight " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc Allelic Composition: Fech^tm1Dab/Fech⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0001570	abnormal circulating enzyme level	"aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc Allelic Composition: Fech^m1Pas/Fech^m1Pas,hem6/hem6⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Fech^m1Pas/Fech^m1Pas,hem6/hem6 Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc Allelic Composition: Fech^m1Pas/Fech^m1Pas,hem6/hem6⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0003657	abnormal erythrocyte lysis	"increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0004147	increased porphyrin level	"elevated concentration of porphyrins or protoporphyrins" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0008387	hypochromic anemia	"hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0010175	leptocytosis	"the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Cbfb^tm1Tno/Cbfb^tm1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0011188	increased erythrocyte protoporphyrin level	"an accumulation of the intermediates of heme biosynthesis in red blood cells" [MGI:csmith]	Show Allelic Composition: Fbxw4^Dac/Fbxw4^Dac,mdac/mdac Genetic Background: involves: SM/Ckc Allelic Composition: Fech^m1Pas/Fech^m1Pas,hem6/hem6⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Fech^m1Pas/Fech^m1Pas,hem6/hem6 Genetic Background: involves: 129 * BALB/c * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024588	Fech / Mus musculus ferrochelatase (Fech), transcript variant 2, mRNA. / P22830* / ferrochelatase*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr