| MP:0000182 | increased circulating LDL cholesterol level | "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000639 | abnormal adrenal gland morphology | "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001783 | decreased white fat amount | "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002275 | abnormal type II pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002499 | chronic inflammation | "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002971 | abnormal brown fat morphology | "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004002 | abnormal jejunum morphology | "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004969 | pale kidney | "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005336 | abnormal inguinal fat pad | "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005337 | abnormal retroperitoneal fat pad | "malformed or aberrant size of the encapsulated adipose tissue found on the dorsal side of the peritoneum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005490 | Clara cell hyperplasia | "increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:48446] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0006320 | abnormal interscapular fat pad | "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008114 | abnormal Kupffer cell morphology | "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008245 | abnormal alveolar macrophage morphology | "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008466 | enlarged mesenteric lymph nodes | "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008843 | absent subcutaneous adipose tissue | "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0008989 | abnormal liver sinusoid morphology | "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0009124 | increased brown fat cell lipid droplet size | "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0009132 | abnormal white fat cell size | "anomaly in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0009289 | decreased epididymal fat pad weight | |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0010810 | increased type II pneumocyte number | "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
Show
Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
