Manteia

ENSMUSG00000025027

Mus musculus

Features

Gene ID:	ENSMUSG00000025027

Biological name :	Xpnpep1

Synonyms :	Xpnpep1 / X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

Possible biological names infered from orthology :	Q9NQW7 / X-prolyl aminopeptidase 1

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	D2
Gene start:	52943417
Gene end:	53040214

Corresponding Affymetrix probe sets:	10468489 (MoGene1.0st) 1422443_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000138097 Ensembl peptide - ENSMUSP00000138233 Ensembl peptide - ENSMUSP00000138250 Ensembl peptide - ENSMUSP00000138473 NCBI entrez gene - 170750 See in Manteia. MGI - MGI:2180003 RefSeq - XM_017318075 RefSeq - NM_133216 RefSeq - XM_011247158 RefSeq - XM_011247159 RefSeq - XM_011247160 RefSeq Peptide - NP_573479 swissprot - S4R228 swissprot - Q3UE92 swissprot - S4R167 swissprot - S4R1I3 Ensembl - ENSMUSG00000025027

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
xpnpep1	ENSDARG00000029011	Danio rerio
XPNPEP1	ENSGALG00000008523	Gallus gallus
Q9NQW7	ENSG00000108039	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
B1AVD1 / Xpnpep2 / X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound / O43895* / X-prolyl aminopeptidase 2*	ENSMUSG00000037005	40

Protein motifs (from Interpro)

Interpro ID	Name
IPR000587	Creatinase, N-terminal
IPR000994	Peptidase M24
IPR001131	Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
IPR029149	Creatinase/Aminopeptidase P/Spt16, N-terminal
IPR032416	Peptidase M24, C-terminal domain
IPR033740	Aminopeptidase P
IPR036005	Creatinase/aminopeptidase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0010815	bradykinin catabolic process	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0004177	aminopeptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0030145	manganese ion binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0070006	metalloaminopeptidase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000286	abnormal mitral valve morphology	"malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000433	microcephaly	"an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0000784	forebrain hypoplasia	"reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002928	abnormal bile duct morphology	"malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0003619	abnormal urine color	"any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003826	abnormal Mullerian duct morphology	"malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0006063	abnormal inferior vena cava morphology	"structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0006064	abnormal superior vena cava morphology	"structural malformation in the principal vein draining blood from the upper portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010490	abnormal inferior vena cava valve morphology	"any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010769	abnormal survival	"deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB/N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013848	subcutaneous edema	"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013875	trigeminal neuroma		Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013966	abnormal infrahyoid muscle morphology		Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013967	abnormal infrahyoid muscle connection		Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013971	blood in lymph vessels		Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013985	abnormal umbilical vein topology	"abnormal position of the umbilical vein in relationship to other umbilical cord structures" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013986	abnormal vitelline vein topology	"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0014001	abnormal vertebral artery topology	"abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0014018	embryo tumor	"presence of an unspecified tumor or aberrant growth in a prenatal orgnaism" [MGI:csmith]	Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0014023	abnormal intestine placement		Show Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr