ENSMUSG00000025137


Mus musculus

Features
Gene ID: ENSMUSG00000025137
  
Biological name :Pcyt2
  
Synonyms : Pcyt2 / phosphate cytidylyltransferase 2, ethanolamine / Q922E4
  
Possible biological names infered from orthology : Q99447
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120610087
Gene end: 120617936
  
Corresponding Affymetrix probe sets: 10393851 (MoGene1.0st)   1420493_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026129
Ensembl peptide - ENSMUSP00000101794
NCBI entrez gene - 68671     See in Manteia.
MGI - MGI:1915921
RefSeq - XM_006534071
RefSeq - NM_024229
RefSeq - XM_006534069
RefSeq - XM_006534070
RefSeq Peptide - NP_001334544
RefSeq Peptide - NP_077191
swissprot - Q3USD5
swissprot - Q922E4
swissprot - A2ABY3
Ensembl - ENSMUSG00000025137
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcyt2ENSDARG00000043003Danio rerio
 PCYT2ENSGALG00000007251Gallus gallus
 PCYT2ENSG00000185813Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004306 ethanolamine-phosphate cytidylyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Pla2g6m1Sein/Pla2g6m1Sein
Genetic Background: C57BL/6JJcl-Pla2g6m1Sein

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025137 Pcyt2 / Q922E4 / phosphate cytidylyltransferase 2, ethanolamine / Q99447*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr