ENSMUSG00000025178


Mus musculus

Features
Gene ID: ENSMUSG00000025178
  
Biological name :Pi4k2a
  
Synonyms : Phosphatidylinositol 4-kinase type 2-alpha / Pi4k2a / Q2TBE6
  
Possible biological names infered from orthology : Q9BTU6
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 42090435
Gene end: 42122218
  
Corresponding Affymetrix probe sets: 10463211 (MoGene1.0st)   1433462_a_at (Mouse Genome 430 2.0 Array)   1454605_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069284
NCBI entrez gene - 84095     See in Manteia.
MGI - MGI:1934031
RefSeq - XM_011247406
RefSeq - NM_145501
RefSeq - XM_011247405
RefSeq Peptide - NP_663476
swissprot - Q2TBE6
Ensembl - ENSMUSG00000025178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pi4k2aENSDARG00000033666Danio rerio
 ENSGALG00000006143Gallus gallus
 PI4K2AENSG00000155252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pi4k2b / Q8CBQ5 / Phosphatidylinositol 4-kinase type 2-beta / Q8TCG2* / AC104662.2*ENSMUSG0000002918657


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002561 basophil degranulation IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0007030 Golgi organization IBA
 biological_processGO:0007032 endosome organization IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031083 BLOC-1 complex IEA
 cellular_componentGO:0031224 intrinsic component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0035838 growing cell tip IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044231 host cell presynaptic membrane IDA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004430 1-phosphatidylinositol 4-kinase activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035651 AP-3 adaptor complex binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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