ENSMUSG00000025245


Mus musculus

Features
Gene ID: ENSMUSG00000025245
  
Biological name :Lztfl1
  
Synonyms : Leucine zipper transcription factor-like protein 1 / Lztfl1 / Q9JHQ5
  
Possible biological names infered from orthology : leucine zipper transcription factor like 1 / Q9NQ48
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F4
Gene start: 123694416
Gene end: 123717697
  
Corresponding Affymetrix probe sets: 10463263 (MoGene1.0st)   10597973 (MoGene1.0st)   1417170_at (Mouse Genome 430 2.0 Array)   1428974_s_at (Mouse Genome 430 2.0 Array)   1431323_at (Mouse Genome 430 2.0 Array)   1435514_at (Mouse Genome 430 2.0 Array)   1460200_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130872
Ensembl peptide - ENSMUSP00000150134
Ensembl peptide - ENSMUSP00000150089
Ensembl peptide - ENSMUSP00000132359
Ensembl peptide - ENSMUSP00000026274
Ensembl peptide - ENSMUSP00000095858
NCBI entrez gene - 93730     See in Manteia.
MGI - MGI:1934860
RefSeq - XM_011243056
RefSeq - NM_033322
RefSeq - XM_006512403
RefSeq Peptide - NP_201579
swissprot - A0A1L1ST13
swissprot - E9Q9P1
swissprot - F6VTH5
swissprot - Q9JHQ5
swissprot - A0A1L1SSX7
swissprot - F6VG18
Ensembl - ENSMUSG00000025245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lztfl1ENSDARG00000105010Danio rerio
 LZTFL1ENSGALG00000033928Gallus gallus
 LZTFL1ENSG00000163818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026157  Leucine zipper transcription factor-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1903565 negative regulation of protein localization to cilium IEA
 biological_processGO:1903568 negative regulation of protein localization to ciliary membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025245 Lztfl1 / Q9JHQ5 / Leucine zipper transcription factor-like protein 1 / Q9NQ48* / leucine zipper transcription factor like 1*  / complex






 

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