ENSMUSG00000025380


Mus musculus

Features
Gene ID: ENSMUSG00000025380
  
Biological name :Fscn2
  
Synonyms : Fascin-2 / Fscn2 / Q32M02
  
Possible biological names infered from orthology : fascin actin-bundling protein 2, retinal / O14926
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 120361534
Gene end: 120368168
  
Corresponding Affymetrix probe sets: 10383345 (MoGene1.0st)   1440605_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026445
NCBI entrez gene - 238021     See in Manteia.
MGI - MGI:2443337
RefSeq - NM_172802
RefSeq - XM_006533259
RefSeq Peptide - NP_766390
swissprot - Q32M02
Ensembl - ENSMUSG00000025380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fscn2aENSDARG00000059574Danio rerio
 fscn2bENSDARG00000074396Danio rerio
 FSCN2ENSGALG00000023354Gallus gallus
 FSCN2ENSG00000186765Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fscn1 / Q61553 / Fascin / Q16658* / fascin actin-bundling protein 1*ENSMUSG0000002958155
Fscn3 / Q9QXW4 / Fascin-3 / Q9NQT6* / fascin actin-bundling protein 3*ENSMUSG0000002970728


Protein motifs (from Interpro)
Interpro ID Name
 IPR008999  Actin-crosslinking
 IPR010431  Fascin
 IPR022768  Fascin domain
 IPR024703  Fascin, metazoans
 IPR030144  Fascin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IBA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0051017 actin filament bundle assembly IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0031941 filamentous actin IBA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

Allelic Composition: Fscn2ahl8/Fscn2ahl8,Cdh23ahl/Cdh23ahl
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fscn2tm1Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2tm2Sykk
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fscn2tm2Sykk/Fscn2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

Allelic Composition: Fscn2ahl8/Fscn2ahl8,Cdh23ahl/Cdh23ahl
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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