ENSMUSG00000029581


Mus musculus

Features
Gene ID: ENSMUSG00000029581
  
Biological name :Fscn1
  
Synonyms : Fascin / Fscn1 / Q61553
  
Possible biological names infered from orthology : fascin actin-bundling protein 1 / Q16658
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 142960343
Gene end: 142973185
  
Corresponding Affymetrix probe sets: 10527158 (MoGene1.0st)   1416514_a_at (Mouse Genome 430 2.0 Array)   1416515_at (Mouse Genome 430 2.0 Array)   1416516_at (Mouse Genome 430 2.0 Array)   1448378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122862
Ensembl peptide - ENSMUSP00000142509
Ensembl peptide - ENSMUSP00000031565
NCBI entrez gene - 14086     See in Manteia.
MGI - MGI:1352745
RefSeq - NM_007984
RefSeq Peptide - NP_032010
swissprot - Q61553
swissprot - A0A0G2JDU7
swissprot - F7BDR1
Ensembl - ENSMUSG00000029581
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fscn1aENSDARG00000059680Danio rerio
 fscn1bENSDARG00000037747Danio rerio
 FSCN1ENSGALG00000021128Gallus gallus
 FSCN1ENSG00000075618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fscn2 / Q32M02 / Fascin-2 / O14926* / fascin actin-bundling protein 2, retinal*ENSMUSG0000002538055
Fscn3 / Q9QXW4 / Fascin-3 / Q9NQT6* / fascin actin-bundling protein 3*ENSMUSG0000002970729


Protein motifs (from Interpro)
Interpro ID Name
 IPR008999  Actin-crosslinking
 IPR010431  Fascin
 IPR022768  Fascin domain
 IPR024703  Fascin, metazoans
 IPR030146  Fascin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007043 cell-cell junction assembly IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IBA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030035 microspike assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0032534 regulation of microvillus assembly IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035089 establishment of apical/basal cell polarity IEA
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005902 microvillus IBA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0031941 filamentous actin IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044393 microspike IEA
 cellular_componentGO:0071437 invadopodium ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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