ENSDARG00000059680


Danio rerio

Features
Gene ID: ENSDARG00000059680
  
Biological name :fscn1a
  
Synonyms : fascin actin-bundling protein 1a / fscn1a
  
Possible biological names infered from orthology : Fascin / fascin actin-bundling protein 1 / FSCN1 / Q16658 / Q61553
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 40576447
Gene end: 40589489
  
Corresponding Affymetrix probe sets: Dr.24928.1.S1_at (Zebrafish Array)   Dr.24928.2.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000077647
swissprot - F1QET7
ZFIN ID - ZDB-GENE-031009-1
Ensembl - ENSDARG00000059680
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FSCN1ENSGALG00000021128Gallus gallus
 FSCN1ENSG00000075618Homo sapiens
 Fscn1ENSMUSG00000029581Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fscn1b / fascin actin-bundling protein 1b / FSCN1* / Q16658* / Q61553* / Fascin * / fascin actin-bundling protein 1*ENSDARG0000003774771
fscn2b / fascin actin-bundling protein 2b, retinal / FSCN2* / O14926* / Q32M02* / Fascin-2 * / fascin actin-bundling protein 2, retinal*ENSDARG0000007439658
fscn2a / fascin actin-bundling protein 2a, retinal / FSCN2* / O14926* / fascin actin-bundling protein 2, retinal*ENSDARG0000005957456


Protein motifs (from Interpro)
Interpro ID Name
 IPR008999  Actin-crosslinking
 IPR010431  Fascin
 IPR022768  Fascin domain
 IPR024703  Fascin, metazoans
 IPR030146  Fascin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IBA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051017 actin filament bundle assembly IBA
 biological_processGO:0090504 epiboly IMP
 biological_processGO:1900107 regulation of nodal signaling pathway IMP
 biological_processGO:1903045 neural crest cell migration involved in sympathetic nervous system development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031941 filamentous actin IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0000076 swim bladder swim bladder morphology , abnormal
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 ZFA:0000112 gut gut decreased amount , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
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 ZFA:0000123 liver liver decreased amount , abnormal
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 ZFA:0000124 liver primordium liver primordium absent , abnormal
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 ZFA:0000416 presumptive endoderm presumptive endoderm decreased amount , abnormal
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 ZFA:0001106 pharyngeal pouch pharyngeal pouch decreased amount , abnormal
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 ZFA:0001194 cranial neural crest cranial neural crest filopodium decreased length , abnormal
cranial neural crest filopodium decreased amount , abnormal
cranial neural crest misrouted , abnormal
cranial neural crest neural crest cell migration process quality , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage absent , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium morphology , abnormal
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 ZFA:0001370 posterior pancreatic bud posterior pancreatic bud absent , abnormal
posterior pancreatic bud decreased amount , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage absent , abnormal
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 ZFA:0001576 sympathetic nervous system sympathetic nervous system malformed , abnormal
sympathetic nervous system decreased size , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 neural crest cell migration process quality , abnormal
pharyngeal arch 1 cranial neural crest misrouted , abnormal
pharyngeal arch 1 morphology , abnormal
pharyngeal arch 1 absent , abnormal
Show

 ZFA:0005775 enteric neuron enteric neuron decreased amount , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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