ENSMUSG00000025427


Mus musculus

Features
Gene ID: ENSMUSG00000025427
  
Biological name :Rnf165
  
Synonyms : E9QAU8 / ring finger protein 165 / Rnf165
  
Possible biological names infered from orthology : Q6ZSG1
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E3
Gene start: 77456110
Gene end: 77565147
  
Corresponding Affymetrix probe sets: 10459827 (MoGene1.0st)   10459835 (MoGene1.0st)   1436114_at (Mouse Genome 430 2.0 Array)   1438829_at (Mouse Genome 430 2.0 Array)   1447404_at (Mouse Genome 430 2.0 Array)   1458303_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138276
Ensembl peptide - ENSMUSP00000138529
Ensembl peptide - ENSMUSP00000138494
Ensembl peptide - ENSMUSP00000026494
NCBI entrez gene - 225743     See in Manteia.
MGI - MGI:2444521
RefSeq - NM_001164504
RefSeq Peptide - NP_001157976
swissprot - A0A0R4J2A4
swissprot - E9QAU8
swissprot - Q19SC8
swissprot - S4R1M1
Ensembl - ENSMUSG00000025427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf165aENSDARG00000077906Danio rerio
 rnf165bENSDARG00000078817Danio rerio
 RNF165ENSGALG00000031018Gallus gallus
 Q6ZSG1ENSG00000141622Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99ML9 / Rnf111 / Mus musculus ring finger 111 (Rnf111), transcript variant 2, mRNA. / Q6ZNA4* / ring finger protein 111*ENSMUSG0000003221742


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011016  Zinc finger, RING-CH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0030163 protein catabolic process IDA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0035136 forelimb morphogenesis IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0060173 limb development IGI
 biological_processGO:0060384 innervation IMP
 biological_processGO:0061061 muscle structure development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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