ENSMUSG00000032217


Mus musculus

Features
Gene ID: ENSMUSG00000032217
  
Biological name :Rnf111
  
Synonyms : Mus musculus ring finger 111 (Rnf111), transcript variant 2, mRNA. / Q99ML9 / Rnf111
  
Possible biological names infered from orthology : Q6ZNA4 / ring finger protein 111
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 70425424
Gene end: 70503725
  
Corresponding Affymetrix probe sets: 10594785 (MoGene1.0st)   1423304_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034739
Ensembl peptide - ENSMUSP00000109225
Ensembl peptide - ENSMUSP00000149445
Ensembl peptide - ENSMUSP00000149501
NCBI entrez gene - 93836     See in Manteia.
MGI - MGI:1934919
RefSeq - XM_017313709
RefSeq - NM_001357494
RefSeq - NM_033604
RefSeq - XM_006511584
RefSeq - XM_006511586
RefSeq - XM_006511587
RefSeq - XM_011242841
RefSeq - XM_006511576
RefSeq - XM_006511577
RefSeq - XM_006511578
RefSeq - XM_006511580
RefSeq - XM_006511581
RefSeq - XM_006511582
RefSeq - XM_006511583
RefSeq Peptide - NP_001344423
RefSeq Peptide - NP_291082
swissprot - Q99ML9
swissprot - A0A1L1SRK3
Ensembl - ENSMUSG00000032217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf111ENSDARG00000078802Danio rerio
 RNF111ENSGALG00000004171Gallus gallus
 Q6ZNA4ENSG00000157450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9QAU8 / Rnf165 / ring finger protein 165 / Q6ZSG1*ENSMUSG0000002542715


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR029306  E3 ubiquitin-protein ligase Arkadia, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0032184 SUMO polymer binding ISS
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction






 

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