ENSMUSG00000025477


Mus musculus

Features
Gene ID: ENSMUSG00000025477
  
Biological name :Inpp5a
  
Synonyms : inositol polyphosphate-5-phosphatase A / Inpp5a
  
Possible biological names infered from orthology : Q14642
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 139389109
Gene end: 139579652
  
Corresponding Affymetrix probe sets: 10558515 (MoGene1.0st)   1433605_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026550
Ensembl peptide - ENSMUSP00000095589
Ensembl peptide - ENSMUSP00000101704
NCBI entrez gene - 212111     See in Manteia.
MGI - MGI:2686961
RefSeq - XM_017322096
RefSeq - NM_001127363
RefSeq - NM_183144
RefSeq - XM_006536162
RefSeq Peptide - NP_001342091
RefSeq Peptide - NP_898967
RefSeq Peptide - NP_001120835
swissprot - Q3TZT4
swissprot - Q7TNC9
swissprot - E9QAS7
Ensembl - ENSMUSG00000025477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5lENSDARG00000053878Danio rerio
 INPP5AENSGALG00000010493Gallus gallus
 INPP5AENSG00000068383Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0046855 inositol phosphate dephosphorylation ISO
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042731 PH domain binding ISO


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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