ENSMUSG00000025481


Mus musculus

Features
Gene ID: ENSMUSG00000025481
  
Biological name :Urah
  
Synonyms : Q9CRB3 / Urah / urate (5-hydroxyiso-) hydrolase
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 140835018
Gene end: 140837966
  
Corresponding Affymetrix probe sets: 10558687 (MoGene1.0st)   1431786_s_at (Mouse Genome 430 2.0 Array)   1455186_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140559
Ensembl peptide - ENSMUSP00000147888
Ensembl peptide - ENSMUSP00000147522
Ensembl peptide - ENSMUSP00000147435
Ensembl peptide - ENSMUSP00000026554
Ensembl peptide - ENSMUSP00000101665
NCBI entrez gene - 76974     See in Manteia.
MGI - MGI:1916142
RefSeq - NM_029821
RefSeq - XM_006536273
RefSeq - XM_006536272
RefSeq Peptide - NP_001334534
RefSeq Peptide - NP_084097
swissprot - A0A1B0GR99
swissprot - Q9CRB3
swissprot - A0A0A0MQC3
swissprot - A0A1B0GSD0
Ensembl - ENSMUSG00000025481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 urahaENSDARG00000100719Danio rerio
 urahbENSDARG00000089331Danio rerio
 URAHENSGALG00000000549Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttr / P07309 / transthyretin / P02766*ENSMUSG0000006180827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000895  Transthyretin/hydroxyisourate hydrolase
 IPR014306  Hydroxyisourate hydrolase
 IPR023416  Transthyretin/hydroxyisourate hydrolase domain
 IPR023419  Transthyretin, conserved site
 IPR036817  Transthyretin/hydroxyisourate hydrolase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006144 purine nucleobase metabolic process IEA
 biological_processGO:0019628 urate catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033971 hydroxyisourate hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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