ENSMUSG00000061808


Mus musculus

Features
Gene ID: ENSMUSG00000061808
  
Biological name :Ttr
  
Synonyms : P07309 / transthyretin / Ttr
  
Possible biological names infered from orthology : P02766
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 20665250
Gene end: 20674324
  
Corresponding Affymetrix probe sets: 10454192 (MoGene1.0st)   1451580_a_at (Mouse Genome 430 2.0 Array)   1454608_x_at (Mouse Genome 430 2.0 Array)   1455913_x_at (Mouse Genome 430 2.0 Array)   1459737_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074783
NCBI entrez gene - 22139     See in Manteia.
MGI - MGI:98865
RefSeq - NM_013697
RefSeq Peptide - NP_038725
swissprot - P07309
swissprot - Q5M9K1
Ensembl - ENSMUSG00000061808
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttrENSDARG00000037191Danio rerio
 ENSGALG00000044733Gallus gallus
 TTRENSGALG00000015143Gallus gallus
 TTRENSG00000118271Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Urah / Q9CRB3 / urate (5-hydroxyiso-) hydrolaseENSMUSG0000002548126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000895  Transthyretin/hydroxyisourate hydrolase
 IPR023416  Transthyretin/hydroxyisourate hydrolase domain
 IPR023418  Transthyretin, thyroxine binding site
 IPR023419  Transthyretin, conserved site
 IPR030178  Transthyretin
 IPR036817  Transthyretin/hydroxyisourate hydrolase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0070327 thyroid hormone transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042562 hormone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070324 thyroid hormone binding IBA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
Non-integrin membrane-ECM interactions
Neutrophil degranulation
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003351 decreased circulating levels of thyroid hormone "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ttrtm1Wsb/Ttrtm1Wsb
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ttrtm1Kymm/Ttrtm1Kymm
Genetic Background: B6.Cg-Ttrtm1Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttr+
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttrtm2(TTR)Kymm
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm/Ttrtm3(TTR*)Kymm

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

 MP:0005444 abnormal retinol metabolism "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:55555]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ttrtm1Wsb/Ttrtm1Wsb
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Ttrtm1Kymm/Ttrtm1Kymm
Genetic Background: B6.Cg-Ttrtm1Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttr+
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttrtm2(TTR)Kymm
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttrtm1Wsb/Ttrtm1Wsb
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Ttrtm1Kymm/Ttrtm1Kymm
Genetic Background: B6.Cg-Ttrtm1Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttr+
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttrtm2(TTR)Kymm
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ttrtm1Wsb/Ttrtm1Wsb
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Ttrtm1Kymm/Ttrtm1Kymm
Genetic Background: B6.Cg-Ttrtm1Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttr+
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

Allelic Composition: Ttrtm2(TTR)Kymm/Ttrtm2(TTR)Kymm
Genetic Background: B6.Cg-Ttrtm2(TTR)Kymm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000061808 Ttr / P07309 / transthyretin / P02766*  / complex
 ENSMUSG00000024990 Rbp4 / Q00724 / Retinol-binding protein 4 / P02753*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr