| MP:0000005 | increased brown fat amount | "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze,Tg(Myh6-Pnpla2)94Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0000008 | increased white fat amount | "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze,Tg(Myh6-Pnpla2)94Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0000188 | abnormal circulating glucose level | "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
|
| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL
|
| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
|
| MP:0001560 | abnormal circulating insulin level | "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001764 | abnormal homeostasis | "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0002127 | abnormal cardiovascular system morphology | "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1
|
| MP:0002626 | increased heart rate | "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
|
| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze,Tg(Myh6-Pnpla2)94Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0002702 | decreased circulating free fatty acid level | "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze,Tg(Myh6-Pnpla2)94Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S * FVB/N
|
| MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
|
| MP:0002970 | abnormal white fat morphology | "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0002971 | abnormal brown fat morphology | "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
|
| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0003221 | abnormal cardiomyocyte apoptosis | "change in the timing or the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0003915 | increased left ventricle weight | "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003948 | abnormal gas homeostasis | "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0003976 | decreased circulating VLDL triglyceride level | "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0004129 | abnormal respiratory quotient | "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005266 | abnormal metabolism | "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005281 | increased fatty acid level | "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6
|
| MP:0005288 | abnormal oxygen consumption | "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005291 | abnormal glucose tolerance | "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005317 | increased triglyceride level | "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S * FVB/N
Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6
|
| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0005418 | abnormal circulating hormone level | "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0005455 | increased weight gain | "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005666 | abnormal adipose tissue physiology | "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0006087 | increased body mass index | "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0008033 | impaired lipolysis | "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0008908 | increased total fat pad weight | "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0009118 | increased white fat cell size | "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0009119 | increased brown fat cell size | "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322] |
Show
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0009285 | increased gonadal fat pad weight | "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
|
| MP:0009292 | increased inguinal fat pad weight | |
Show
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
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| MP:0009294 | increased interscapular fat pad weight | |
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Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
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| MP:0009302 | increased renal fat pad weight | |
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Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
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| MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
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| MP:0010018 | lung vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
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| MP:0010378 | increased respiratory quotient | "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
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| MP:0010724 | thick interventricular septum | "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
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| MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
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Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
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| MP:0012236 | abnormal cholangiocyte morphology | "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800] |
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Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
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| MP:0012270 | cardiac edema | "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna] |
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Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
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| MP:0014071 | increased cardiac muscle glycogen level | "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna] |
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Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze
Genetic Background: involves: 129P2/OlaHsd
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| MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
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| MP:0020234 | decreased basal metabolism | "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV] |
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Allelic Composition: Pnpla2tm1Gam/Pnpla2tm1Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA
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| MP:0030017 | decreased adipocyte glucose uptake | "reduced ability of adipocytes to take in glucose" [MGI:anna] |
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Allelic Composition: Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
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