ENSMUSG00000025735


Mus musculus

Features
Gene ID: ENSMUSG00000025735
  
Biological name :Rhbdl1
  
Synonyms : Q8VC82 / Rhbdl1 / Rhomboid-related protein 1
  
Possible biological names infered from orthology : O75783 / rhomboid like 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25834465
Gene end: 25837295
  
Corresponding Affymetrix probe sets: 10449061 (MoGene1.0st)   1426094_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026831
Ensembl peptide - ENSMUSP00000138927
Ensembl peptide - ENSMUSP00000139046
NCBI entrez gene - 214951     See in Manteia.
MGI - MGI:2384891
RefSeq - XM_011246361
RefSeq - NM_144816
RefSeq - XM_006524022
RefSeq Peptide - NP_659065
swissprot - Q8VC82
swissprot - V9GX09
swissprot - V9GX92
swissprot - Q3USF1
Ensembl - ENSMUSG00000025735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhbdl1ENSDARG00000087040Danio rerio
 RHBDL1ENSGALG00000028345Gallus gallus
 O75783ENSG00000103269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P58873 / Rhbdl3 / Rhomboid-related protein 3 / P58872* / rhomboid like 3*ENSMUSG0000001769255
A2AGA4 / Rhbdl2 / Rhomboid-related protein 2 Rhomboid-related protein 2, N-terminal fragment Rhomboid-related protein 2, C-terminal fragment / Q9NX52* / rhomboid like 2*ENSMUSG0000004333329


Protein motifs (from Interpro)
Interpro ID Name
 IPR002610  Peptidase S54, rhomboid
 IPR011992  EF-hand domain pair
 IPR017213  Peptidase S54, rhomboid, metazoan
 IPR022764  Peptidase S54, rhomboid domain
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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