ENSMUSG00000025968


Mus musculus

Features
Gene ID: ENSMUSG00000025968
  
Biological name :Ndufs1
  
Synonyms : NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / Ndufs1 / Q91VD9
  
Possible biological names infered from orthology : NADH:ubiquinone oxidoreductase core subunit S1 / P28331
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 63143596
Gene end: 63176833
  
Corresponding Affymetrix probe sets: 10355084 (MoGene1.0st)   1425143_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126621
Ensembl peptide - ENSMUSP00000141190
Ensembl peptide - ENSMUSP00000140819
Ensembl peptide - ENSMUSP00000140467
Ensembl peptide - ENSMUSP00000140307
Ensembl peptide - ENSMUSP00000140072
Ensembl peptide - ENSMUSP00000139664
Ensembl peptide - ENSMUSP00000027111
NCBI entrez gene - 227197     See in Manteia.
MGI - MGI:2443241
RefSeq - XM_006495952
RefSeq - NM_001160038
RefSeq - NM_001160039
RefSeq - NM_001160040
RefSeq - NM_145518
RefSeq Peptide - NP_001153512
RefSeq Peptide - NP_663493
RefSeq Peptide - NP_001153510
RefSeq Peptide - NP_001153511
swissprot - A0A087WQR0
swissprot - A0A087WQ77
swissprot - A0A087WRY4
swissprot - A0A087WP77
swissprot - Q91VD9
swissprot - A0A087WSU3
swissprot - A0A087WR47
Ensembl - ENSMUSG00000025968
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndufs1ENSDARG00000028546Danio rerio
 NDUFS1ENSGALG00000008606Gallus gallus
 NDUFS1ENSG00000023228Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000283  NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR006656  Molybdopterin oxidoreductase
 IPR006963  Molybdopterin oxidoreductase, 4Fe-4S domain
 IPR010228  NADH:ubiquinone oxidoreductase, subunit G
 IPR012675  Beta-grasp domain superfamily
 IPR015405  NADH-quinone oxidoreductase, chain G, C-terminal
 IPR019574  NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
 IPR036010  2Fe-2S ferredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008637 apoptotic mitochondrial changes ISS
 biological_processGO:0042773 ATP synthesis coupled electron transport IEA
 biological_processGO:0045333 cellular respiration ISS
 biological_processGO:0046034 ATP metabolic process ISS
 biological_processGO:0051881 regulation of mitochondrial membrane potential ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072593 reactive oxygen species metabolic process ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005747 mitochondrial respiratory chain complex I IBA
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070469 respiratory chain IEA
 molecular_functionGO:0003954 NADH dehydrogenase activity IEA
 molecular_functionGO:0008137 NADH dehydrogenase (ubiquinone) activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016651 oxidoreductase activity, acting on NAD(P)H IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Respiratory electron transport
Complex I biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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