ENSMUSG00000026018


Mus musculus

Features
Gene ID: ENSMUSG00000026018
  
Biological name :Ica1l
  
Synonyms : Ica1l / Mus musculus islet cell autoantigen 1-like (Ica1l), transcript variant 4, mRNA. / Q3TY65
  
Possible biological names infered from orthology : islet cell autoantigen 1 like / Q8NDH6
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 59982490
Gene end: 60043184
  
Corresponding Affymetrix probe sets: 10355024 (MoGene1.0st)   1431049_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027172
Ensembl peptide - ENSMUSP00000140520
Ensembl peptide - ENSMUSP00000141103
NCBI entrez gene - 70375     See in Manteia.
MGI - MGI:1917625
RefSeq - XM_017312255
RefSeq - NM_001316694
RefSeq - NM_001357296
RefSeq - NM_027407
RefSeq - XM_006496270
RefSeq - XM_006496272
RefSeq - XM_011238597
RefSeq - XM_017312238
RefSeq - XM_017312240
RefSeq - XM_006496269
RefSeq Peptide - NP_001303623
RefSeq Peptide - NP_001344225
RefSeq Peptide - NP_081683
swissprot - Q3TY65
swissprot - A0A087WSM1
Ensembl - ENSMUSG00000026018
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ical1ENSDARG00000057688Danio rerio
 ICA1LENSG00000163596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ica1 / P97411 / Islet cell autoantigen 1 / Q05084*ENSMUSG0000006299549


Protein motifs (from Interpro)
Interpro ID Name
 IPR006723  Islet cell autoantigen Ica1, C-terminal
 IPR010504  Arfaptin homology (AH) domain
 IPR024114  Islet cell autoantigen 1/Ica1-like
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007286 spermatid development IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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