ENSMUSG00000062995


Mus musculus

Features
Gene ID: ENSMUSG00000062995
  
Biological name :Ica1
  
Synonyms : Ica1 / Islet cell autoantigen 1 / P97411
  
Possible biological names infered from orthology : Q05084
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 8630527
Gene end: 8778488
  
Corresponding Affymetrix probe sets: 10543120 (MoGene1.0st)   1417901_a_at (Mouse Genome 430 2.0 Array)   1431644_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116861
Ensembl peptide - ENSMUSP00000138459
Ensembl peptide - ENSMUSP00000118194
Ensembl peptide - ENSMUSP00000118010
Ensembl peptide - ENSMUSP00000117734
Ensembl peptide - ENSMUSP00000117112
Ensembl peptide - ENSMUSP00000040062
Ensembl peptide - ENSMUSP00000111180
Ensembl peptide - ENSMUSP00000111181
Ensembl peptide - ENSMUSP00000111182
NCBI entrez gene - 15893     See in Manteia.
MGI - MGI:96391
RefSeq - XM_006504995
RefSeq - NM_001252266
RefSeq - NM_010492
RefSeq - XM_006504993
RefSeq - XM_006504994
RefSeq Peptide - NP_034622
RefSeq Peptide - NP_001239195
swissprot - S4R217
swissprot - D3Z699
swissprot - P97411
swissprot - D3Z119
swissprot - D3Z118
swissprot - D3Z020
swissprot - F7BG11
swissprot - F6UY19
swissprot - D3Z376
Ensembl - ENSMUSG00000062995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ica1ENSDARG00000042608Danio rerio
 ICA1ENSGALG00000010708Gallus gallus
 ICA1ENSG00000003147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ica1l / Q3TY65 / Mus musculus islet cell autoantigen 1-like (Ica1l), transcript variant 4, mRNA. / Q8NDH6* / islet cell autoantigen 1 like*ENSMUSG0000002601844


Protein motifs (from Interpro)
Interpro ID Name
 IPR006723  Islet cell autoantigen Ica1, C-terminal
 IPR010504  Arfaptin homology (AH) domain
 IPR024114  Islet cell autoantigen 1/Ica1-like
 IPR027267  AH/BAR domain superfamily
 IPR030796  Islet cell autoantigen 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion NAS
 biological_processGO:0050796 regulation of insulin secretion IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dyrk3tm1Dowo/Dyrk3tm1Dowo,Eportm2Jni/Eportm2Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Ica1tm1Mdos/Ica1tm1Mdos,Ica1lem1Jxia/Ica1lem1Jxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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