ENSMUSG00000026109


Mus musculus

Features
Gene ID: ENSMUSG00000026109
  
Biological name :Tmeff2
  
Synonyms : Q9QYM9 / Tmeff2 / Tomoregulin-2
  
Possible biological names infered from orthology : Q9UIK5 / transmembrane protein with EGF like and two follistatin like domains 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 50900647
Gene end: 51187270
  
Corresponding Affymetrix probe sets: 10346150 (MoGene1.0st)   1419073_at (Mouse Genome 430 2.0 Array)   1441598_at (Mouse Genome 430 2.0 Array)   1454132_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110212
Ensembl peptide - ENSMUSP00000080533
NCBI entrez gene - 56363     See in Manteia.
MGI - MGI:1861735
RefSeq - NM_019790
RefSeq Peptide - NP_062764
swissprot - A0A0R4J1J9
swissprot - Q9QYM9
Ensembl - ENSMUSG00000026109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmeff2aENSDARG00000051824Danio rerio
 tmeff2bENSDARG00000058699Danio rerio
 TMEFF2ENSGALG00000007759Gallus gallus
 Q9UIK5ENSG00000144339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PFE7 / Tmeff1 / Mus musculus transmembrane protein with EGF-like and two follistatin-like domains 1 (Tmeff1), transcript variant 1, mRNA. / Q8IYR6* / transmembrane protein with EGF like a...ENSMUSG0000002834746


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002350  Kazal domain
 IPR013032  EGF-like, conserved site
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0044319 wound healing, spreading of cells IEA
 biological_processGO:0045720 negative regulation of integrin biosynthetic process IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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