ENSMUSG00000026113


Mus musculus

Features
Gene ID: ENSMUSG00000026113
  
Biological name :Inpp4a
  
Synonyms : Inpp4a / type I inositol 3,4-bisphosphate 4-phosphatase isoform 5
  
Possible biological names infered from orthology : inositol polyphosphate-4-phosphatase type I A / Q96PE3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 37299865
Gene end: 37410736
  
Corresponding Affymetrix probe sets: 10345580 (MoGene1.0st)   1421360_at (Mouse Genome 430 2.0 Array)   1436616_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115249
Ensembl peptide - ENSMUSP00000110583
Ensembl peptide - ENSMUSP00000121107
Ensembl peptide - ENSMUSP00000142118
Ensembl peptide - ENSMUSP00000130443
Ensembl peptide - ENSMUSP00000123071
Ensembl peptide - ENSMUSP00000121803
Ensembl peptide - ENSMUSP00000121518
Ensembl peptide - ENSMUSP00000027287
Ensembl peptide - ENSMUSP00000057233
NCBI entrez gene - 269180     See in Manteia.
MGI - MGI:1931123
RefSeq - XM_017320952
RefSeq - XM_006496006
RefSeq - XM_006496008
RefSeq - XM_006496009
RefSeq - XM_006496010
RefSeq - XM_006496011
RefSeq - XM_006496013
RefSeq - XM_006496014
RefSeq - XM_006496015
RefSeq - XM_006496016
RefSeq - XM_006496017
RefSeq - XM_006496018
RefSeq - XM_006496019
RefSeq - XM_006496020
RefSeq - XM_011238525
RefSeq - XM_017320934
RefSeq - NM_001290797
RefSeq - NM_001290798
RefSeq - NM_001290799
RefSeq - NM_030266
RefSeq - NM_172971
RefSeq Peptide - NP_766559
RefSeq Peptide - NP_001277728
RefSeq Peptide - NP_084542
RefSeq Peptide - NP_001277726
RefSeq Peptide - NP_001277727
swissprot - F6R4N2
swissprot - F6V2U0
swissprot - E9QAD0
swissprot - Q3UEQ1
swissprot - A0A0A6YXS5
swissprot - A0A0R4J0Q2
swissprot - E9Q9A0
swissprot - D3Z230
swissprot - D3YUL8
swissprot - D3YUD3
Ensembl - ENSMUSG00000026113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp4abENSDARG00000070995Danio rerio
 INPP4AENSGALG00000029709Gallus gallus
 INPP4AENSG00000040933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp4b / Q6P1Y8 / Type II inositol 3,4-bisphosphate 4-phosphatase / O15327* / inositol polyphosphate-4-phosphatase type II B*ENSMUSG0000003794039


Protein motifs (from Interpro)
Interpro ID Name
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Inpp4atm1Tsak/Inpp4awbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Inpp4atm1Tsak/Inpp4awbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Elovl4tm2Kzh/Elovl4tm2Kzh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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